PMID: 6405429Jan 1, 1983Paper

Dexamethasone and stress-induced analgesia

Psychopharmacology
S MousaD Couri

Abstract

Analgesia induced in rats by cold-water swim stress and measured by the tail-flick and hot-plate methods was significantly antagonized after IP pretreatment for 3 days with 8 mg/kg dexamethasone. The analgesia developed by the cold-water swim stressor was also attenuated by 1 mg/kg naloxone. These results suggest that the corticosteroids may have a role in modulating stress-induced analgesia and that the adrenal-pituitary axis modulates the endogenous opiate system. These conclusions are based on recent reports that indicate the release of the opiate-like peptide beta-endorphin and adrenocorticotropin (ACTH) from the pituitary are increased by acute stress and inhibited by administration of the synthetic glucocorticoid dexamethasone.

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Citations

Jan 1, 1986·Physiology & Behavior·E Kramer, R J Bodnar
Apr 1, 1993·Physiology & Behavior·D D KellyR J Bodnar
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·E S SperberR J Bodnar
Sep 1, 1988·Pharmacology, Biochemistry, and Behavior·J A RobertsonR J Bodnar
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·S A MousaG R Van Loon
Mar 1, 1987·Peptides·P D Butler, R J Bodnar
Dec 1, 1988·Brain Research Bulletin·R J Hamm, J S Knisely
Sep 1, 1994·Experimental Gerontology·O GhirardiL Angelucci
May 4, 2010·Physiology & Behavior·Marie Hoeger BementSandra K Hunter
Apr 28, 2009·Progress in Neurobiology·Ryan K Butler, David P Finn
Sep 1, 1987·Developmental Psychobiology·R J Hamm, J S Knisely
Jan 1, 1986·Annals of the New York Academy of Sciences·R J Bodnar
Sep 25, 2020·Cellular and Molecular Neurobiology·Grace C Rossi, Richard J Bodnar

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