PMID: 8938730Jan 1, 1996Paper

Dexamethasone and stress upregulate Kv1.5 K+ channel gene expression in rat ventricular myocytes

Neuropharmacology
E S LevitanK Takimoto

Abstract

Hormones may produce long-term effects on excitability by regulating K+ channel gene expression. Previous studies demonstrated that administration of dexamethasone, a glucocorticoid receptor agonist, to adrenalectomized rats, rapidly induces Kv1.5 K+ channel expression in the ventricle of the hear. Here, RNase protection assays and Northern blots are used to examine the cell type specificity of dexamethasone action and to test whether Kv1.5 gene expression can be regulated by a physiological stimulus. We show that Kv1.5 mRNA expression in the central nervous system is highest in the hypothalamus. However, dexamethasone treatment of adrenalectomized rats fails to affect Kv1.5 mRNA levels in hypothalamus or lung. In contrast, dramatic upregulation of Kv1.5 mRNA is seen in skeletal muscle and pituitary. Increased Kv1.5 message also found in isolated ventricular cardiomyocytes following in vivo treatment with dexamethasone. Finally, it is shown that cold stress of intact rats significantly increases cardiac Kv1.5 mRNA expression. We conclude that dexamethasone induction of Kv1.5 gene is tissue-specific. Furthermore, our results suggest that stress may act via glucocorticoids to increase Kv1.5 gene expression in ventricular cardiomy...Continue Reading

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May 1, 1980·Neuroendocrinology·R H LenoxJ L Meyerhoff
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Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·S A Mackler, J H Eberwine
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Citations

Oct 20, 1998·Journal of Neurobiology·E S Levitan, K Takimoto
Nov 16, 2001·Trends in Cardiovascular Medicine·S NattelG Schram
Oct 2, 1998·British Journal of Pharmacology·M C LimF A Antoni
Aug 14, 2003·Pacing and Clinical Electrophysiology : PACE·Antonio Pacifico, Philip D Henry
Jan 27, 2010·The Journal of General Physiology·Núria VillalongaAntonio Felipe
Jun 23, 1998·Canadian Journal of Physiology and Pharmacology·D FedidaX Zhang
Feb 5, 2002·Annual Review of Physiology·Dan M RodenMark E Anderson
Dec 25, 2004·Physiological Reviews·Steven C HebertWenhui Wang
Sep 20, 2012·Endocrinology·Rongqin RenJohn A Cidlowski
Dec 15, 2011·Biochemical and Biophysical Research Communications·Carlos MunozFlorian Lang
Jun 1, 2017·Journal of Cardiovascular Medicine·Milena AsteMichele Brignole

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