Dexamethasone eluting cochlear implant: Histological study in animal model

Cochlear Implants International
Mohammad FarhadiClaude Jolly

Abstract

New cochlear implant (CI) designs and developments in implantation techniques have revolutionized the management of hearing loss. However, cochlear implantation still has some disadvantages, such as its potential to initiate an inflammatory response that may lead to further hair cell damage. Recent topics of investigation have been the effect of glucocorticoids on inflammatory tissue response reduction, glucocorticoid dosage levels, and drug-delivery methods. In the present study, dexamethasone delivery via a drug-eluting CI was evaluated histologically through assessing inflammatory cell infiltration. Thirty healthy, adult male guinea pigs were included and randomly assigned to one of three surgical groups that underwent cochleostomy of the basal turn. The experimental group (Group 1) of 12 animals were implanted with a dexamethasone-loaded silicone elastomer shaped like a CI electrode. The primary control group (Group 2) of 12 animals were implanted with a simple CI (non-eluting). A second control group (Group 3) of six animals underwent cochleostomy only. Inflammatory responses were compared between groups by evaluating inflammatory cell infiltration in inner-ear specimens at days 3 and 13. The Mann‐Whitney test revealed red...Continue Reading

References

Oct 1, 1992·Journal of Neuroscience Methods·G G KingmaM W Myers
Nov 1, 1993·Hearing Research·J N BrownA L Nuttall
Jul 1, 1996·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·K E Rarey, L M Curtis
May 7, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Joseph B Nadol, Donald K Eddington
May 15, 2004·Acta Oto-laryngologica·Jan KieferChristoph von Ilberg
Oct 7, 2004·Hearing Research·Keiji TakemuraToshio Yamashita
Apr 5, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Brian D Herr, Sam J Marzo
Jul 18, 2006·Hearing Research·Barbara CanlonYeasmin Tahera
Aug 8, 2006·Advances in Oto-rhino-laryngology·Joseph B Nadol, Donald K Eddington
May 2, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Adrien A EshraghiThomas R Van De Water
Dec 7, 2007·Audiology & Neuro-otology·David P JamesStephen J O'Leary
Jun 25, 2008·Hearing Research·Jeffrey L HendricksDavid C Martin
Sep 9, 2008·Experimental Neurology·Steven BackhouseRobert Shepherd
Sep 27, 2008·The Laryngoscope·Richard J ViveroThomas R Van de Water

❮ Previous
Next ❯

Citations

Jul 11, 2013·Nanomedicine·Christian Oliver PritzRudolf Glueckert
Jan 18, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·P CeschiG Paasche
Sep 3, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Laura AstolfiAlessandro Martini
Mar 14, 2014·Cochlear Implants International·Dimitra StathopoulosCarrie Newbold
Sep 1, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ya LiuJan Kiefer
Oct 26, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Arne LiebauStefan K Plontke
May 13, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jonathon LoStephen John O'leary
Aug 8, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yann NguyenOlivier Sterkers
May 26, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jennifer T O'MalleyJoseph B Nadol
Aug 22, 2018·Cochlear Implants International·Scott ChambersRobert Cowan
Oct 18, 2019·Cochlear Implants International·Karina NeedhamRobert Cowan
Jul 14, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Raquel Manrique-HuarteManuel Manrique
Jan 1, 2020·Laryngoscope Investigative Otolaryngology·Megan J FoggiaMarlan R Hansen
Aug 6, 2019·Frontiers in Cellular Neuroscience·Yin RenKonstantina M Stankovic
Dec 12, 2019·Frontiers in Cellular Neuroscience·Adrien A EshraghiJeenu Mittal
May 29, 2020·Hearing Research·Kate M BrodyStephen J O'Leary
Apr 6, 2021·Acta Oto-laryngologica·Anandhan Dhanasingh, Ingeborg Hochmair

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Adrien A EshraghiRonen Nazarian
Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Céline RichardFred H Linthicum
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
J T McElveenR T Miyamoto
© 2022 Meta ULC. All rights reserved