PMID: 3754860May 1, 1986Paper

Dexamethasone increases adult rat lung surfactant lipids

Journal of Applied Physiology
S L Young, R A Silbajoris

Abstract

Prenatal administration of glucocorticoids stimulates epithelial cell maturation and induces a precocious development of pulmonary surfactant. The response of the adult lung to steroid administration is less well understood. We administered dexamethasone (2 mg X kg-1 X day-1) to adult male rats for 1 wk by daily subcutaneous injection. After pentobarbital anesthesia we lavaged the lungs and also isolated lamellar bodies from the tissue. Lipid analyses of the extracellular and intracellular surfactant compartments showed two- to fourfold greater amounts of total phospholipids and disaturated phosphatidylcholine compared with control. These changes were not found in kidney nor liver and were not present in plasma membrane, mitochondrial, or microsomal fractions from lungs. Morphometric analyses of the type II cells showed that anatomic measures of the lamellar body pool did not increase. We conclude that glucocorticoids have a significant effect to increase lung surfactant lipid pools of adult rat lungs by changing the phospholipid content of lamellar bodies, without changing lamellar body volume.

Citations

Nov 14, 1997·The American Journal of Physiology·M IkegamiJ A Whitsett
Feb 11, 2005·Journal of Applied Physiology·Peter BärtschErik R Swenson
Nov 1, 1990·Experimental Lung Research·K A KennedyJ B Warshaw
Jul 1, 1991·American Journal of Respiratory Cell and Molecular Biology·J H FisherT Hofmann
Jan 17, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sandra R BatesAron B Fisher
Jan 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M IkegamiA H Jobe
Sep 6, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B A Hills, Y Chen
Apr 13, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philip L BallardMichael A Matthay
Mar 11, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E N AtochinaJ M Beck
Mar 14, 2001·American Journal of Respiratory Cell and Molecular Biology·J M ShannonR J Mason
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·L C Sullivan, S Orgeig
Aug 26, 2015·High Altitude Medicine & Biology·Heimo Mairbäurl, Emel Baloglu
Mar 23, 2013·British Journal of Pharmacology·Loganathan Chitra, Rathanam Boopathy
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·A H Jobe, M Ikegami
Nov 21, 1987·Biochimica Et Biophysica Acta·R Dahiya, T A Brasitus
Apr 1, 1989·Respiration Physiology·L BrondelJ P Besombes
Jul 10, 2003·Pulmonary Pharmacology & Therapeutics·Chung-Ming ChenHsun-Hui Hsu
May 11, 1999·The Journal of Laboratory and Clinical Medicine·M F BeersJ M Beck

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