Dexamethasone-induced immunosuppression: a rabbit model

Veterinary Immunology and Immunopathology
Edita JeklovaMartin Faldyna

Abstract

Rabbits are often used as animal models for experimental purposes; in many cases steroid-induced immunosuppression is necessary. The aim of this study was to characterise a model of immunosuppression in rabbits, based on changes in the lymphocyte subset distribution, changes in proliferative capacity of lymphocytes and activity of neutrophils 1, 3 and 7 days after the administration of 2mg/kg dexamethasone phosphate (DXP) three times at 6-h intervals. In peripheral blood, neutrophilia and lymphopenia together with eosinopenia, monocytopenia and basopenia in the absence of leukocytosis was detected. One day after DXP administration the absolute numbers of all lymphocyte subsets decreased in the blood, whereas in bone marrow, absolute numbers of all lymphocyte subsets increased significantly, except CD79alpha(+) cells that increased only in relative numbers. The effect of DXP on lymphocytes from the spleen, mesenteric and popliteal lymph nodes was less pronounced. In the thymus, DXP led to a marked reduction of the relative and absolute numbers of CD4(+)CD8(+) thymocytes. The proliferative capacity of lymphocytes after concanavalin A stimulation was lower in the peripheral blood and spleen only on day 1, no changes were detected ...Continue Reading

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Jul 7, 2007·Veterinary Immunology and Immunopathology·Edita JeklovaMartin Faldyna

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Citations

Dec 19, 2014·Avian Diseases·Anil J ThachilKakambi V Nagaraja
Jan 29, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sergey S SereginAndrea Amalfitano
Apr 12, 2016·Dermatologic Therapy·Yi-Xiu BaiHong-Duo Chen
Jan 5, 2013·Research in Veterinary Science·Tomasz MaślankaDawid Jędrzkiewicz
Jun 29, 2017·PloS One·Marina Banuet-MartínezKarina Acevedo-Whitehouse
Nov 1, 2013·Journal of Virology·G A MaglennonJ Doorbar
Mar 10, 2020·BioMed Research International·Diana A Martínez BJaiver E Rosas Pérez
Mar 16, 2021·Research in Veterinary Science·Jörg MayerRobert M Gogal

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