Dexamethasone Intravitreal Implant for Diabetic Macular Edema During Pregnancy

American Journal of Ophthalmology
Michael ConcilladoMichael Larsen

Abstract

To describe the management of diabetic macular edema during pregnancy with the use of a dexamethasone slow-release intravitreal implant. Retrospective, observational, consecutive case series. The study included 5 pregnant women who presented with diabetic macular edema during pregnancy in the period from 2011 to 2014. Review of charts and photographs comprised best-corrected visual acuity (BCVA), foveal center field thickness assessed by optical coherence tomography, blood pressure, glycated hemoglobin, medications, and changes in such parameters after implant injection. Diabetic macular edema involving the foveal center was observed between gestational weeks 9 and 23 in 10 eyes of 5 patients. Dexamethasone intravitreal implant injection was given 10 times in 9 eyes with a mean preinjection center field retinal thickness of 535 μm (range, 239-727 μm) and a mean preinjection best-corrected visual acuity (BCVA) of 63 approximated Early Treatment Diabetic Retinopathy Study (approxETDRS) letters (range, 50-77 letters). One eye was unavailable for follow-up. In 7 of 8 eyes injection was followed, within 3 weeks, by a greater than 145 μm reduction in foveal center field thickness and in 6 of 8 eyes by an increase in BCVA of 5 or more...Continue Reading

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Citations

Aug 28, 2016·Drugs & Aging·Beatriz AbadiaLuis Pablo
Feb 3, 2018·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Andrzej GrzybowskiUNKNOWN Euretina Board
May 12, 2017·Retinal Cases & Brief Reports·Vittorio CapuanoGiuseppe Querques
Nov 7, 2019·American Journal of Therapeutics·Angela Napoli
Feb 9, 2020·Ophthalmology and Therapy·Anne-Sofie PetriYousif Subhi
Jan 23, 2018·Diabetologia·Ute Schaefer-GrafUNKNOWN Diabetic Pregnancy Study Group
May 1, 2021·International Journal of Molecular Sciences·Enrique Antonio Alfonso-MuñozCarmen Desco
Oct 29, 2021·Indian Journal of Ophthalmology·Priya R ChandrasekaranRaja Narayanan

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