PMID: 7525827Sep 1, 1994Paper

Dexamethasone potentiates the stimulatory effect of insulin-like growth factor-I on collagen production in cultured human fibroblasts

The Journal of Endocrinology
J L Bird, J A Tyler

Abstract

We examined the effects of insulin-like growth factor-I (IGF-I) and dexamethasone on the production of collagen by cultures of human infant foreskin fibroblasts, and the interaction between these two factors. IGF-I at 500 ng/ml maximally increased collagen accumulation fourfold. Collagen was increased twofold relative to total protein production. Dexamethasone at a concentration of 1 mumol/l reduced collagen production by between 25% and 40% in unstimulated cells and those cultured with up to 100 ng IGF-I/ml. However, dexamethasone did potentiate collagen production in cells stimulated with 250 ng IGF-I/ml. This potentiation was independent of any effects of IGF-I or dexamethasone on prostaglandin (PG)E2 production. Transforming growth factor-beta (TGF-beta) is also a potent stimulator of collagen formation. However, no potentiation of TGF-beta-stimulated collagen production by dexamethasone was apparent. The mechanism by which dexamethasone potentiates IGF-I-stimulated collagen production was investigated. Dexamethasone treatment increased IGF-I binding to the type 1 IGF receptor without altering the binding affinity. Dexamethasone also attenuated the secretion of IGF-binding proteins by IGF-I-maintained cells.

Citations

Dec 18, 2001·Archives of Oral Biology·A Tilakaratne, M Soory
Mar 21, 2012·Scandinavian Journal of Medicine & Science in Sports·K M HeinemeierM Kjaer
May 8, 2009·Acta Orthopaedica·Margaret Wan Nar WongKwong Man Lee
Feb 15, 2014·Advances in Wound Care·Mohammadreza PakyariAziz Ghahary
Mar 14, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ruhangiz T KilaniAziz Ghahary
Nov 20, 2019·Cellular and Molecular Life Sciences : CMLS·Ewa KarnaJerzy A Palka
May 5, 2004·Clinical Orthopaedics and Related Research·Margaret Wan Nar WongKai Ming Chan

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