PMID: 6535745Jan 1, 1984Paper

Dexamethasone suppression test in autistic children

Folia Psychiatrica Et Neurologica Japonica
Y HoshinoH Kumashiro

Abstract

A dexamethasone suppression test (DST) was carried out on autistic and other handicapped children to investigate the function of the hypothalamo-pituitary adrenal axis (HPA-axis). The subjects were 19 autistic children consisting of 11 relatively well-developed and eight poorly-developed children. The control groups were 26 normal volunteers, 19 patients with schizophrenia and 15 children with mental retardation (MR) or minimal brain dysfunction (MBD). The DST procedures followed the Carroll method. As a result, all of the normal volunteers and 19 schizophrenic patients showed normal response (suppressor). Nine of the 11 well-developed autistic children exhibited suppressor, while all of the poorly-developed children showed an abnormal response (non-suppressor). Nine of the 10 children with MR and all of the five children with MBD were suppressor. These results suggest that there might be a dysfunction in the HPA-axis of the poorly-developed autistic children.

References

Feb 1, 1980·Acta Psychiatrica Scandinavica·J L Nuller, M N Ostroumova
May 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·T HällströmP A Lundberg

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Citations

Sep 1, 1992·Journal of Autism and Developmental Disorders·A L Richdale, M R Prior
Dec 1, 1990·Journal of Autism and Developmental Disorders·G M RealmutoB D Garfinkel
Nov 11, 2005·Progress in Neurobiology·Peter McCaffery, Curtis K Deutsch
Aug 12, 2014·Psychoneuroendocrinology·Leah GirshkinMelissa J Green
Aug 27, 2018·Autism Research : Official Journal of the International Society for Autism Research·Julie Lounds TaylorBlythe A Corbett
Mar 19, 2020·Diseases·Benedikt Andreas GasserMarkus Georg Mohaupt

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