Dexamethasone treatment attenuates early seawater instillation-induced acute lung injury in rabbits

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Ding XinminXu Qinzhi

Abstract

There is very little evidence on the value of giving corticoids in cases of seawater drowning induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Therefore, this study aimed to investigate whether dexamethasone treatment can attenuate seawater instillation-induced acute lung injury in rabbits. Seawater (4 ml/kg body weight) was instilled into the lower trachea of ventilated, anesthetized rabbits. Then these rabbits were assigned randomly 20 min later to receive intravenous injection of 1mg/kg body weight of dexamethasone (dissolving in 2 ml of normal saline) or 2 ml of normal saline. All animals demonstrated immediate drops in arterial oxygen tension (PaO2) and the total thoracic compliance, which were significantly improved after 2 h of dexamethasone treatment. Histopathological study also indicated that dexamethasone treatment markedly attenuated lung histopathological changes, alveolar hemorrhage and inflammatory cells infiltration with evidence of decreasing of myeloperoxidase (MPO) activity and tumor necrosis factor-alpha (TNF-alpha) concentration in lung tissue. In addition, dexamethasone treatment reduced extravascular lung water and lung epithelial-endothelial barrier permeability, up-regulated the...Continue Reading

Citations

Jul 11, 2013·Oxidative Medicine and Cellular Longevity·Haizhen MoWenke Zhou
Oct 30, 2014·International Journal of Molecular Sciences·Minlong ZhangFaguang Jin
May 23, 2012·Respiratory Physiology & Neurobiology·Feng HanZhichao Li
Jul 6, 2016·Frontiers in Pediatrics·Andreas Schwingshackl, Gianfranco Umberto Meduri
Apr 24, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Weifeng ShenHonghai Wu
Jun 8, 2017·Experimental and Therapeutic Medicine·Faguang Jin, Congcong Li
Sep 29, 2019·International Journal of Molecular Sciences·Daniela MokraJuraj Mokry
Jan 14, 2021·Journal of Cellular and Molecular Medicine·Caiming XuHailong Chen

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