Dexamethasone/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices

Biomaterials
T HickeyFrancis Moussy

Abstract

The purpose of this research was to develop polylactic-co-glycolic acid (PLGA) microspheres for continuous delivery of dexamethasone for over a 1-month period, in an effort to suppress the acute and chronic inflammatory reactions to implants such as biosensors, which interfere with their functionality. The microspheres were prepared using an oil-in-water emulsion technique. The oil phase was composed of 9:1 dichloromethane to methanol with dissolved PLGA and dexamethasone. Some microspheres were predegraded for 1 or 2 weeks. Ten percent of polyethylene glycol was added to the oil phase in alternative formulations to delay drug release. The in vitro release studies were performed in a constant temperature (37 C) warm room, in phosphate-buffered saline at sink conditions. Drug loading and release rates were determined by HPLC-UV analysis. The standard microsphere systems did not provide the desired release profile since, following an initial burst release, a delay of 2 weeks occurred prior to continuous drug release. Predegraded microspheres started to release dexamethasone immediately but the rate of release decreased after only 2 weeks. A mixed standard and predegraded microsphere system was used to avoid this delay and to prov...Continue Reading

References

Feb 1, 1977·Journal of Pharmaceutical Sciences·R A Lipper, W I Higuchi
Jun 13, 1986·Journal of Chromatography·D LamiableH Choisy
Jan 1, 1983·Journal of Pharmaceutical Sciences·D S HsiehR Langer
Mar 18, 1994·Science·R GrefR Langer
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·V M KeatingsP J Barnes
Nov 22, 1997·Journal of Biomedical Materials Research·A A SharkawyW M Reichert
Jan 10, 1998·Journal of Pharmaceutical Sciences·R P BatyckyD A Edwards
May 23, 1998·Journal of Biomedical Materials Research·A A SharkawyW M Reichert
May 23, 1998·Journal of Biomedical Materials Research·A A SharkawyW M Reichert
Apr 1, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·A GezeJ P Benoit
Apr 22, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·R V DiazC Evora
Apr 25, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MurakamiY Kawashima
Nov 7, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·G D RosaF Quaglia
Feb 22, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H M RedheadL Illum

❮ Previous
Next ❯

Citations

Sep 21, 2012·Biomedical Microdevices·Robert A CroceFaquir C Jain
Jan 23, 2009·Journal of Materials Science. Materials in Medicine·G J S DawesJ Duszczyk
Aug 12, 2009·Journal of Materials Science. Materials in Medicine·G J S DawesJ Duszczyk
Jan 10, 2006·Pharmaceutical Research·Susan S D'Souza, Patrick P DeLuca
Jul 31, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Susan D'SouzaPatrick DeLuca
Feb 8, 2013·Chemical Reviews·Scott P NicholsMark H Schoenfisch
Feb 3, 2005·Diabetes Technology & Therapeutics·Karl E Friedl
Nov 7, 2012·Tissue Engineering. Part B, Reviews·Jeong-Hui ParkIvan B Wall
Dec 16, 2005·AAPS PharmSciTech·Susan S D'Souza, Patrick P DeLuca
Feb 10, 2010·The AAPS Journal·Jacqueline M MoraisDiane J Burgess
Jul 24, 2012·Therapeutic Delivery·Kyung Jae Jeong, Daniel S Kohane
Sep 21, 2011·Nanomedicine·Elizabeth HoodVladimir Muzykantov
Jan 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yan WangDiane J Burgess
Jan 1, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Punna Rao RaviRahul Vats
May 3, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Jing ZhouJodie L Lutkenhaus
Mar 13, 2014·Journal of Drug Delivery·Susan D'SouzaPatrick P Deluca
Jul 3, 2013·International Journal of Pharmaceutics·Yan Wang, Diane J Burgess
Jan 29, 2013·Drug Delivery and Translational Research·Balakrishnan SivaramanAnand Ramamurthi
Sep 27, 2012·Molecular Pharmaceutics·Sam N RothsteinSteven R Little
Sep 25, 2015·Biosensors & Bioelectronics·M AvulaF Solzbacher
Feb 6, 2014·Journal of Pharmaceutical Sciences·Muralikrishnan AngamuthuS Narasimha Murthy
Aug 21, 2012·International Journal of Pharmaceutics·Amélie GaignauxKarim Amighi
Nov 7, 2009·Journal of Pharmaceutical Sciences·Yahya E ChoonaraLisa C du Toit
Nov 26, 2010·International Journal of Pharmaceutics·Ainhoa MuruaRosa M Hernández
May 18, 2010·International Journal of Pharmaceutics·Archana Rawat, Diane J Burgess
Oct 6, 2009·International Journal of Pharmaceutics·Upkar BhardwajDiane J Burgess
Nov 26, 2008·Biomaterials·Byung Soo KimMoon Suk Kim
Sep 25, 2015·Lab on a Chip·Kee Scholten, Ellis Meng
Nov 19, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yanfang YangXiaoyan Yuan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.