Dexfenfluramine induces Fos-like immunoreactivity in discrete brain regions in rats

Brain Research Bulletin
B H Li, N E Rowland

Abstract

Administration of the anorectic agent, dexfenfluramine (DFEN) to rats induced dose- and time-dependent expression of Fos-like immunoreactivity in several discrete brain regions of rats. At moderate doses, the regions showing the most intense Fos immunostaining included the bed nucleus of the stria terminalis, the lateral part of the central amygdala, midline thalamic nuclei, habenular nuclei, lateral parabrachial nucleus, and nucleus of the solitary tract. It is suggested that these nuclei, many of which are known to receive gustatory or visceral input, may form part of a functional circuit via which DFEN modulates food intake. Rats that were made hungry by either food deprivation or administration of insulin also showed induction of Fos in several brain regions, but only that in the supramamillary/ventral tegmental area was suppressed by pretreatment with an anorectic dose of DFEN. The functional significance of these sites requires further investigation.

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Citations

May 20, 1998·Journal of Molecular Neuroscience : MN·A S HazellA M Hakim
Feb 19, 1999·Brain Research·N E Rowland, R M Richmond
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Kenny J Simansky, Danielle M Nicklous
Jan 1, 1997·Brain Research Bulletin·M J WaynerD L Armstrong
Sep 1, 1996·Nutrition·N E RowlandB H Li
Aug 26, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J G VeeningB Olivier
Nov 23, 2005·Behavioral Neuroscience·Yasunobu YasoshimaTakashi Yamamoto
Jan 22, 2003·The European Journal of Neuroscience·Peter G CliftonColin T Dourish
Apr 9, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Deniz AtalayerNeil E Rowland
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W E LyonsL Tessarollo
Aug 19, 2014·Neuroscience and Biobehavioral Reviews·Philip L JohnsonAnantha Shekhar
Oct 23, 2012·Progress in Neurobiology·Heinz Steiner, Vincent Van Waes
Jun 18, 2003·The Journal of Comparative Neurology·Linda EngströmAnders Blomqvist
Oct 24, 2007·Pharmacology & Therapeutics·John D Fernstrom, Sujean Choi
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Koki InoueEric P Zorrilla

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