Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism

Brain Research
Dongpei YinJianning Zhang

Abstract

Early brain injury (EBI) plays a pivotal role in the prognosis of patients with subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective α2 receptor agonist, is reported to exert multiple protective effects in many neurological diseases. This study was designed to investigate whether DEX had neuroprotective functions in EBI after SAH, and to explore the possible mechanisms. The SAH model was established by an endovascular perforation in adult male Sprague-Dawley (SD) rats. DEX (25 µg/kg) or vehicle was administered intraperitoneally 2 h after SAH. Neurological deficits, brain oedema, inflammation, BBB damage, and cell apoptosis at 24 h after SAH were evaluated. Additionally, the expression of components of the Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway, and the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome were also assessed. We demonstrated that DEX treatment improved neurological scores, alleviated brain oedema, reduced the permeability of the blood-brain barrier (BBB), and up-regulated the expression of tight junction proteins. DEX treatment could reduce the neutrophil infiltration, microglial activation, and pro-inflammatory ...Continue Reading

Citations

Jan 7, 2020·The International Journal of Neuroscience·Qunhui WangXuan Chen
Feb 29, 2020·Neurology·Hajime TakaseJosephine Lok
Mar 16, 2019·Frontiers in Physiology·Kelly Q ZhouJoanne O Davidson
Jan 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui ShiXiao-Dong Peng
Feb 8, 2020·Dose-response : a Publication of International Hormesis Society·Jinqiao WangHongjuan Li
Apr 29, 2021·Neural Regeneration Research·Guang-Ping LangYing-Ying Han
Jul 3, 2021·International Journal of Molecular Sciences·Umeshkumar Athiraman, Gregory J Zipfel

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