Dexmedetomidine constant rate infusion for 24 hours during and after propofol or isoflurane anaesthesia in dogs

Veterinary Anaesthesia and Analgesia
Guan-Yu LinLudo J Hellebrekers

Abstract

To evaluate cardiovascular and respiratory effects and pharmacokinetics of a 24-hour intravenous constant rate infusion (CRI) of dexmedetomidine (DMED) during and after propofol (PRO) or isoflurane (ISO) anaesthesia in dogs. Prospective, randomized, cross-over study. Ten healthy adult Beagles. Instrumented dogs received a DMED-loading bolus (25 microg m(-2)) at time 0 followed by a 24-hour CRI (25 microg m(-2) hour(-1)), with PRO or ISO induction/maintenance of anaesthesia during the first 2 hours (PRO and ISO treatment groups, respectively). Cardiovascular, respiratory, blood gas, airway gas, serum chemistry variables and DMED plasma concentration data were collected at -15, 5, 15, 30, 45, 60, 90 and 120 minutes. A number of cardiorespiratory and tissue oxygenation variables were calculated from the above data. After the 2-hours of anaesthesia, heart and respiratory rates and electrocardiograms were recorded and DMED plasma concentrations were determined for up to 26 hours. Vasopressor effects and the decrease in heart rate (HR) and cardiac index induced by DMED were greater for PRO than ISO, but were within clinically acceptable ranges. Adequate oxygenation was maintained above the critical O(2) delivery level. The overall in...Continue Reading

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Citations

Jan 28, 2012·American Journal of Veterinary Research·André EscobarJan E Ilkiw
Apr 29, 2014·Research in Veterinary Science·S Quirós CarmonaR J Gómez-Villamandos
Nov 16, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Hugo van OostromJoost J Uilenreef
Jun 3, 2010·Topics in Companion Animal Medicine·Amandeep S Chohan
Dec 2, 2015·Veterinary Anaesthesia and Analgesia·Rocio NavarreteJuan Morgaz
Aug 16, 2014·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Randi DreesChristopher J François
Dec 5, 2014·Journal of Veterinary Emergency and Critical Care·Miriely S DinizPaulo do Nascimento
Aug 2, 2014·Veterinary Anaesthesia and Analgesia·Peter J Pascoe
Jul 30, 2014·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Randi DreesChristopher J François
Sep 19, 2014·PloS One·Carlos M Acevedo-ArciquePedro Sanchez-Aparicio
Feb 22, 2018·American Journal of Veterinary Research·Lilian T NishimuraEwaldo de Mattos-Junior

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