Dexmedetomidine in anaesthesia

Current Opinion in Anaesthesiology
Andrea Paris, Peter H Tonner

Abstract

The development of dexmedetomidine, a potent and highly selective alpha2-adrenoceptor agonist, has created new interest in the use of alpha2-adrenoceptor agonists, and has led to its evaluation in various yet non-approved perioperative settings. The current review focuses on the usefulness of dexmedetomidine in anaesthesia practice. Recently acquired knowledge and experience with dexmedetomidine in perioperative use will be presented and discussed in the context of known pharmacological properties. Dexmedetomidine offers beneficial pharmacological properties, providing dose-dependent sedation, analgesia, sympatholysis and anxiolysis without relevant respiratory depression. The side-effects are predictable from the pharmacological profile of (2-adrenoceptor agonists. In particular, the unique sedative properties of dexmedetomidine resulted in several interesting applications in anaesthesia practice, promising benefits in the perioperative use of this compound. However, dexmedetomidine was approved for sedation in the intensive care unit in the USA in 1999, and administration in anaesthesia practice remains an 'off-label' use. Further studies are needed to establish the role of dexmedetomidine in the perioperative period.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J W LomasneyR J Lefkowitz
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W ReganB K Kobilka
Jul 12, 1995·Annals of the New York Academy of Sciences·D B Bylund
Oct 1, 1995·Journal of Cardiothoracic and Vascular Anesthesia·J JalonenM Valtonen
Jun 22, 1999·European Journal of Pharmacology·J JolkkonenJ Sivenius
Mar 24, 2000·Drugs·N BhanaK J McClellan
May 18, 2000·The New England Journal of Medicine·J P KressJ B Hall
Oct 25, 2000·Anesthesiology·T Kamibayashi, M Maze
Nov 1, 2000·Critical Care : the Official Journal of the Critical Care Forum·R M VennR M Grounds
Feb 24, 2001·Reviews of Physiology, Biochemistry and Pharmacology·L Hein
Apr 27, 2001·Anesthesia and Analgesia·A Y BekkerW Doyle
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Carolyn A FairbanksGeorge L Wilcox
Jan 24, 2002·Nature·Howard A RockmanRobert J Lefkowitz
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie PhilippLutz Hein
Aug 10, 2002·Anesthesiology·Koji TakadaMervyn Maze
Jan 29, 2003·Anesthesiology·Gerald A Maccioli
Jun 27, 2003·Journal of Neurosurgical Anesthesiology·John ArdAlex Bekker
Sep 30, 2003·Southern Medical Journal·Joseph D TobiasPierantonio Russo

❮ Previous
Next ❯

Citations

Jan 18, 2012·Revista brasileira de anestesiologia·Joana Afonso, Flávio Reis
Jun 30, 2011·Indian Journal of Anaesthesia·Sukhminder Jit Singh BajwaSps Goraya
Aug 23, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Teneille Emma Gofton
Aug 25, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Melik SeyrekHasan B Ulusoy
Nov 16, 2010·Anesthesiology Clinics·Usha RamadhyaniBobby D Nossaman
Apr 20, 2010·Journal of Clinical Anesthesia·Takayuki KunisawaHiroshi Iwasaki
Feb 2, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sanser GulBektas Acikgoz
Oct 13, 2009·Burns : Journal of the International Society for Burn Injuries·Fatih ZorAhmet Cosar
Apr 14, 2009·Anesthesiology Clinics·Douglas C Shook, Robert M Savage
Oct 24, 2012·Case Reports in Anesthesiology·Christopher Allen-John WebbBrigid Colleen Flynn
Jun 13, 2009·Acta Anaesthesiologica Scandinavica·M CanS Acikgoz
Apr 24, 2013·CNS Neuroscience & Therapeutics·Shuang-Shuang LiHua Xu
Jun 30, 2015·Critical Care Clinics·Mark Oldham, Margaret A Pisani
Mar 24, 2012·Revista brasileira de anestesiologia·Kemal GulsoyBayazit Dikmen
Jun 9, 2016·Journal of Anaesthesiology, Clinical Pharmacology·Safiya I Shaikh, Sarala B Mahesh
Apr 1, 2009·Medical Journal, Armed Forces India·Tvsp Murthy
Aug 25, 2016·Journal of Clinical Anesthesia·Hersh PatelTessa Kate Huncke
May 26, 2016·Hospital Practice·Vicente Cés Souza-DantasJorge Salluh
Jul 30, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Safinaz KarabayirliNebil Ark
Sep 7, 2016·Drug Development and Industrial Pharmacy·Aiwei LiPhilip Chi Lip Kwok
Apr 28, 2017·International Neurourology Journal·Kwanwoo Shin
Apr 28, 2017·International Neurourology Journal·Je Hoon ParkDeok Won Lee
Dec 13, 2016·JBI Database of Systematic Reviews and Implementation Reports·John Nguyen, Noel Nacpil
Oct 7, 2008·The Annals of Otology, Rhinology, and Laryngology·Ryan J JenseNicole Maronian
Oct 6, 2016·Korean journal of anesthesiology·Douk-Keun YoonJihyun An
Dec 7, 2010·The American Journal of Hospice & Palliative Care·Eric Prommer
Jul 17, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Andrew M Slupe, Jeffrey R Kirsch
Jul 20, 2016·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Mika SetoToshihiro Kikuta
Oct 7, 2006·The Tohoku Journal of Experimental Medicine·Zerrin OzkoseSahin Yardim

❮ Previous
Next ❯

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Related Papers

Current Opinion in Critical Care
D B CoursinG A Maccioli
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Joseph D Tobias
© 2021 Meta ULC. All rights reserved