Dexmedetomidine Protects Against Neurological Dysfunction in a Mouse Intracerebral Hemorrhage Model by Inhibiting Mitochondrial Dysfunction-Derived Oxidative Stress

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Jing Huang, Qiang Jiang

Abstract

Intracerebral hemorrhage (ICH) is a subtype of stroke with high disability and mortality. Dexmedetomidine (Dex) has been shown to provide neuroprotection in several neurological diseases. The aim of present study was to investigate the effects of Dex on ICH-induced neurological deficits and brain injury and the underlying mechanisms. ICH mouse model was established by intracerebral injection of autologous blood, followed by Dex or vehicle treatment. Neurological function, brain water content, neuronal activity, and oxidative parameters were determined. The protein expressions of peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), uncoupling protein 2, and manganese-dependent superoxide dismutase were examined by western blotting. Dex administration significantly inhibited ICH-induced the memory impairment, dyskinesia, brain edema, and neuron loss. In addition, ICH-induced the increase in brain oxidative stress level was markedly attenuated after Dex treatment, as evidenced by increased glutathione peroxidase and superoxide dismutase levels and reduced malondialdehyde and nitric oxide levels. Compared with vehicle-treated ICH mice, Dex-treated ICH mice showed significantly decreased intracellular reactive ...Continue Reading

Citations

Nov 28, 2019·Cell Biochemistry and Function·Wenxun LiuQingshan Ye
Aug 28, 2020·Journal of Clinical Medicine·Mohamed MahmoudKeira P Mason
Nov 14, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Siobhan CrillyPaul R Kasher
Mar 11, 2021·Oxidative Medicine and Cellular Longevity·Zhenjia YaoGaiqing Wang
Mar 16, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Xiaojian WengJianer Du
Jun 24, 2021·Neurochemical Research·Xiaolan XieKai Qin
Jul 30, 2021·Brain Hemorrhages·Jingsong Ruan, Yao Yao
Dec 4, 2020·Aging and Disease·Anwen ShaoJianmin Zhang
Sep 26, 2021·The European Journal of Neuroscience·Kantarakorn UnchitiSiriporn C Chattipakorn

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