Dexmedetomidine reduces the incidence of fentanyl-induced cough: a double-blind, randomized, and placebo-controlled study.

Upsala Journal of Medical Sciences
Liang HeRu-Ping Dai

Abstract

The incidence of fentanyl-induced cough (FIC) during induction of general anesthesia varies around 40% and is undesirable. It increases intracranial, intraocular, and intra-abdominal pressures. This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexmedetomidine (DEX) pretreatment on the incidence and severity of FIC. Altogether 300 patients undergoing elective surgical procedures were randomly allocated into three groups (I, II, III; n = 100) and administered intravenously, over 10 min, 10 mL isotonic saline, DEX 0.5 μg/kg in 10 mL isotonic saline, or DEX 1 μg/kg in 10 mL isotonic saline, respectively. All groups subsequently received a fentanyl (4.0 μg/kg) intravenous push. The incidence and severity of cough were recorded for 1 min after fentanyl administration. The incidence of FIC was 61%, 40%, and 18% in groups I, II, and III, respectively (P < 0.05 for treatment groups II and III versus control group I). There was no significant difference in the severity or onset time of cough, or hemodynamic variables, among the three groups. . Intravenous DEX (0.5 μg/kg or 1 μg/kg) immediately before the administration of intravenous fentanyl (4.0 μg/kg) significantly reduced the incidence of FIC.

References

Mar 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Anil AgarwalUttam Singh
Aug 18, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chin-Shuang LinMartin S Mok
Feb 3, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chandra Kant PandeyPrabhat Kumar Singh
Feb 3, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Christoph J Schlimp, Franz J Wiedermann
Aug 13, 2005·Acta Anaesthesiologica Scandinavica·G GulerA Boyaci
Aug 24, 2005·Anesthesia and Analgesia·Jui-An LinChih-Shung Wong
Aug 30, 2005·Journal of Pharmacological Sciences·Motomu Tanaka, Kei Maruyama
Jul 29, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Tsutomu OshimaShuji Dohi
Jun 21, 2007·Acta Anaesthesiologica Scandinavica·H-C HorngC-T Wu
Apr 2, 2008·British Journal of Anaesthesia·S ViloK T Olkkola
Oct 9, 2008·Acta Anaesthesiologica Scandinavica·U Schäpermeier, H-B Hopf
Oct 5, 2010·Pharmacological Reports : PR·Qing AiMingHao An

❮ Previous
Next ❯

Citations

Jan 1, 2014·Annals of Medical and Health Sciences Research·Sj Bajwa, A Kulshrestha
Oct 25, 2014·Upsala Journal of Medical Sciences·Liang HeRong Zhu
Dec 25, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Abolfazl FirouzianAlieh Zamani Kiasari
Oct 1, 2016·Journal of Clinical Anesthesia·Li ShuyingLuo Dong
Oct 9, 2013·Korean journal of anesthesiology·Kyung Jee LimMae Hwa Kang
Dec 17, 2020·Frontiers in Pharmacology·Rong ChenQing-Tao Meng

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

Statistical Product for Social Sciences ( SPSS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.