Dexmedetomidine versus remifentanil in postoperative pain control after spinal surgery: a randomized controlled study

BMC Anesthesiology
Wonjung HwangJin Joo

Abstract

Total intravenous anesthesia (TIVA) is used widely in spinal surgery because inhalational anesthetics are known to decrease the amplitude of motor evoked potentials. Presently, dexmedetomidine is used as an adjuvant for propofol-based TIVA. We compared the effects of remifentanil and dexmedetomidine on pain intensity as well as the analgesic requirements after post-anesthesia care unit (PACU) discharge in patients undergoing spinal surgery. Forty patients scheduled for posterior lumbar interbody fusion (PLIF) surgery under general anesthesia were enrolled. Anesthesia was maintained using propofol at 3-12 mg/kg/h and remifentanil at 0.01-0.2 μg/kg/min in Remifentanil group or dexmedetomidine at 0.01-0.02 μg/kg/min in Dexmedetomidine group, keeping the bispectral index between 40 and 60. Patient-controlled analgesia (PCA) made of hydromophone was applied once the patients opened their eyes in the PACU. The visual analog scale (VAS) score, PCA dosage administered, and postoperative nausea and vomiting (PONV) were recorded at the time of discharge from the PACU (T1) and at 2 (T2), 8 (T3), 24 (T4), and 48 hours (T5) after surgery. The VAS score in Remifentanil group was significantly higher than that in Dexmedetomidine group at imme...Continue Reading

References

Jul 1, 1992·Anesthesiology·M F Watcha, P F White
Jan 1, 1994·Anaesthesia·G N Kenny
May 1, 1997·British Journal of Anaesthesia·H Kehlet
Jun 22, 1999·Lancet·D B Carr, L C Goudas
Nov 1, 2000·Critical Care : the Official Journal of the Critical Care Forum·R M VennR M Grounds
Mar 2, 2006·Anesthesiology·Martin S Angst, J David Clark
Mar 7, 2006·Journal of Clinical Anesthesia·James M FeldRanga C Ananda
Mar 26, 2010·Methods in Molecular Biology·Igor Kissin
Sep 16, 2011·Current Medical Research and Opinion·Lauren A McQueen-ShadfarAshraf S Habib
Aug 8, 2012·Korean journal of anesthesiology·Ju-Hee Park, Jae-Young Kwon
May 7, 2013·Korean journal of anesthesiology·Cheol LeeJi-Na Kim

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Citations

Aug 20, 2015·Journal of Craniovertebral Junction and Spine·Sukhminder Jit Singh Bajwa, Rudrashish Haldar
Oct 27, 2016·Pain Practice : the Official Journal of World Institute of Pain·Harold S MinkowitzPamela P Palmer
Mar 7, 2018·The Cochrane Database of Systematic Reviews·Dallas DuncanDuminda N Wijeysundera
Feb 3, 2018·Pain Practice : the Official Journal of World Institute of Pain·Sergio TerracinaFederico Bilotta
Oct 27, 2018·Journal of Neurosurgical Anesthesiology·Nan LinAdrian W Gelb
Sep 5, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ki Jinn ChinVincent Chan
Apr 3, 2020·Current Pain and Headache Reports·Alan David KayeElyse M Cornett
Jan 15, 2021·The Spine Journal : Official Journal of the North American Spine Society·Bertrand DebonoHans D de Boer
Dec 2, 2019·Best Practice & Research. Clinical Anaesthesiology·Helene Beloeil
May 13, 2019·Anaesthesia Critical Care & Pain Medicine·H Beloeil
Aug 14, 2021·Anesthesiology·Patrice ForgetHans D de Boer
Aug 17, 2021·European Journal of Anaesthesiology·Piet WaelkensUNKNOWN PROSPECT Working group∗∗ of the European Society of Regional Anaesthesia and Pain therapy (ESRA)

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Methods Mentioned

BETA
PCA

Software Mentioned

SPSS

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