Dexmethylphenidate extended release: in attention-deficit hyperactivity disorder.

Drugs
Dean M Robinson, Gillian M Keating

Abstract

Dexmethylphenidate extended release (XR) is an orally administered, bimodal release, capsule formulation of the active d-enantiomer of methylphenidate (MPH), which inhibits dopamine and norepinephrine (noradrenaline) reuptake to increase their concentration in the extraneuronal space. A single dose of dexmethylphenidate XR mimics the pharmacokinetic profile of two doses of dexmethylphenidate immediate-release formulation administered 4 hours apart, albeit with less fluctuation in plasma concentration. Once-daily dexmethylphenidate XR was more effective than placebo in reducing attention-deficit hyperactivity disorder (ADHD) symptom scores in children, adolescents and adults with ADHD in four randomised, double-blind, placebo-controlled trials of up to 7 weeks' duration. In crossover trials in children (aged 6-12 years), dexmethylphenidate XR 20 mg/day reduced mean ADHD symptom scores 1 hour after administration (by 43% in one trial) and was significantly better than placebo for up to 12 hours. Dexmethylphenidate XR 5-30 mg/day reduced mean ADHD symptom scores by 49%, while scores declined by 16% with placebo in a 7-week trial in children and adolescents (aged 6-17 years). Dexmethylphenidate XR 20, 30 or 40 mg/day reduced ADHD s...Continue Reading

References

Oct 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·L L GreenhillK Wells
Nov 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·T J SpencerT E Wilens
Jan 11, 2000·Clinical Pharmacokinetics·H C KimkoD R Abernethy
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Steve K TeoVikram D Khetani
Jun 14, 2005·Journal of Occupational and Environmental Medicine·Ronald C KesslerT Bedirhan Ustün

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Citations

Dec 25, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Natalie L LeVasseurKennerly S Patrick
Dec 4, 2008·Human Psychopharmacology·Kennerly S PatrickMario A González
Oct 23, 2008·CNS Spectrums·Mark A Stein

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