PMID: 6160725Sep 1, 1980Paper

Dextran-induced release of serotonin from isolated rat peritoneal mast cells

Acta Pharmacologica Et Toxicologica
J Berstad

Abstract

Dextran (9 mg/ml incubate) was found to induce a serotonin (5-HT) release from isolated rat peritoneal mast cells of about 10% within an incubation period of 5 min. at 37 degrees. The extent of release was not increased by using higher concentrations of dextran or by increasing the incubation period from 5 to 20 min. The dextran-induced release of 5-HT was increased to 50-60% when the mast cells were preincubated with phosphatidylserine (PS) in doses of 2.6-4.3 microgram/ml incubate. Higher concentrations of PS alone induced a rapid 5-HT release of approximately 50-60%. The 5-HT release process studied was found to possess both similarities and dissimilarities with the previously described dextran-induced release process of histamine, also studied in isolated rat peritoneal mast cells. The results supported previous indirect evidence of a 5-HT release from mast cells in the early phase of the dextran-induced anaphylactoid reaction in the rat.

References

Feb 1, 1978·Acta Pharmacologica Et Toxicologica·G BriseidJ Kristoffersen
Sep 10, 1971·Science·A GothM Knoohuizen
Aug 1, 1972·The Journal of Pharmacy and Pharmacology·T H HanahoeW Wieczorek
Nov 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·J H Baxter
Dec 1, 1972·British Journal of Pharmacology·J C Foreman, J L Mongar
May 1, 1973·The Journal of Pharmacy and Pharmacology·T H HanahoeG B West
Apr 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·G W ASHCROFTE J MACDOUGALL

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