Dextrans and the formation of pulmonary metastases after intravenous tumour cell injection in rats non-sensitive to dextran.

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
L Ivarsson, C M Rudenstam

Abstract

This study showed, that in a syngeneic tumour-host system in rats non-sensitive to dextran, dextran 40 and dextran 100 did not stimulate metastasis formation after intravenous tumour cell injection, neither when given as intravenous pretreatment nor when given in the tumour cell suspension. Dextran 1000 stimulated the formation of metastases in both these situations. Disturbed microcirculation, intravascular coagulation and effects upon the tumour cell membrane appear to be the main resons, why dextran 1000 stimulated metastasis formation under the experimental conditions used.

Citations

Jan 2, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·L Ivarsson
Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·G SkolnikL Ivarsson
Jan 1, 1991·Journal of Cancer Research and Clinical Oncology·U NannmarkG Skolnik
Jul 1, 1988·Clinical & Experimental Metastasis·G BlomqvistU Bagge
Mar 1, 1989·Clinical & Experimental Metastasis·G SkolnikH Ahlman
Oct 1, 1988·European Journal of Cancer & Clinical Oncology·G BlomqvistG Skolnik
Apr 15, 1984·International Journal of Cancer. Journal International Du Cancer·G SkolnikH Ahlman

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