Dextroamphetamine with morphine: respiratory effects

Journal of Clinical Pharmacology
D L BourkeA N Karabelas

Abstract

The combination of dextroamphetamine and morphine has been shown to be synergistic for analgesia and antagonistic for most other effects. However, the claim that dextroamphetamine antagonizes the respiratory depression caused by morphine has not been well substantiated. In this double-blind study, we investigated respiratory effects, including resting respiration, isohypercapnic ventilation, CO2 response, dose response, and duration of these effects with dextroamphetamine alone and in combination with morphine. Dextroamphetamine alone (0.215 mg/kg) caused increases in minute ventilation and a leftward shift of the CO2 response curve that lasted for less than 2 hours. Dextroamphetamine combined with low-dose morphine (0.15 mg/kg) antagonized respiratory depression throughout the 5-hour observation period. Dextroamphetamine combined with high-dose morphine (0.30 mg/kg) was unable to completely antagonize depressed ventilation, and some residual effects of morphine persisted at 23 hours.

References

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Sep 18, 1954·Journal of the American Medical Association·L LASAGNA, H K BEECHER
May 17, 1947·Nature·R H THORPP OFNER

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Citations

Jan 1, 1995·Journal of Psychosomatic Research·C J JohnsonJ E Dimsdale
Mar 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John GrabowskiJoy Schmitz

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