PMID: 8941509Nov 1, 1996Paper

Dextromethorphan affects ventilation differently in male and female rats

Journal of Applied Physiology
E H Schlenker

Abstract

Subcutaneous administration of aspartic acid results in a long-lasting but reversible depression of ventilation in male but not in female rats. Aspartic acid acts on N-methyl-D-aspartate receptors. The present study tested the hypothesis that a noncompetitive N-methyl-D-aspartate-receptor antagonist, dextromethorphan (Dex), would depress ventilation in female rats and stimulate it in male rats. Moreover, Dex administered prior to aspartic acid should prevent the aspartic acid-induced depression of ventilation in male rats. In female rats, Dex caused a 30% depression of ventilation relative to saline at 5 and 10 mg/kg (P < 0.01) but not at the highest dose (20 mg/kg). In male rats, Dex had no effect on ventilation. At a dose of 20 mg/kg, Dex depressed oxygen consumption to 50% of the saline value at all time points in female rats (P < 0.001) and in male rats 45 and 60 min after administration. The time points when Dex depressed ventilation and oxygen consumption were different in female rats, suggesting that the depression of ventilation was not the result of a depression in oxygen consumption. During a hypercapnic challenge (7% CO2), female rats treated with 5 and 10 mg/kg of Dex exhibited a smaller increase in ventilatory resp...Continue Reading

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Citations

Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S D LeeG A Farkas
Sep 5, 2006·Neuroreport·Anne M ComiMary Ann Wilson
May 17, 2002·Journal of Applied Physiology·Yijiang Shi, Evelyn H Schlenker
Aug 25, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Luciane H GargaglioniLuis Gustavo A Patrone

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