PMID: 9174243May 20, 1997Paper

Dextromethorphan ameliorates effects of neonatal hypoxia on brain morphology and seizure threshold in rats

Brain Research. Developmental Brain Research
N LaroiaR Guillet

Abstract

Hypoxic injury to the brain is mediated in part by NMDA receptors. Therefore, NMDA receptor blockade with dextromethorphan (DM), a non-competitive channel blocker, was hypothesized to ameliorate injury even when given after the hypoxic insult. Rats were exposed to 8% oxygen for 3 h on postnatal day 7. Within 20 min of exposure, animals received 30 mg/kg i.p. DM or normal saline. Littermates maintained in room air for 3 h also received DM or saline. At 14 days of age, 7 days after exposure, cortical thickness and hippocampal area were measured. At 70-90 days of age, approximately two months after exposure, in a separate group of rats, seizure threshold using pentylenetetrazol (PTZ) and passive avoidance learning and retention were determined. There were no gross changes in cellular morphology and no evidence for cellular necrosis in any of the exposure groups. However, cortical thickness was decreased in animals exposed to hypoxia. DM administration prevented this decrease. Hippocampal area was unaffected. Seizure susceptibility in adulthood was increased in animals exposed to hypoxia in the neonatal period. DM prevented the decrease in seizure threshold. There was no difference in passive avoidance learning or retention as a fu...Continue Reading

References

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Jan 2, 1997·Brain Research. Developmental Brain Research·S Fisher, R Guillet

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Citations

Oct 26, 2002·European Journal of Pharmacology·Geng-Chang YehChum-Lin Hu
Dec 5, 1998·Brain Research. Developmental Brain Research·L R MentW B Stewart
Feb 1, 2002·Neurochemistry International·Daniel KondziellaUrsula Sonnewald
Apr 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·F M Vaccarino, L R Ment
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Lavinia AlbériAnne M Comi
Jan 31, 2016·Pharmacology & Therapeutics·Linda NguyenRae R Matsumoto
Oct 6, 2015·Journal of Neuroscience Methods·Hongyu SunFrances E Jensen
Nov 8, 2011·Epilepsy & Behavior : E&B·Mehdi Ghasemi, Steven C Schachter
Mar 10, 2001·Mental Retardation and Developmental Disabilities Research Reviews·J J Volpe
May 24, 2017·Frontiers in Cellular Neuroscience·Lancelot J MillarZoltán Molnár
Dec 12, 2020·Cells·Aisling Leavy, Eva M Jimenez Mateos

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