PMID: 3768695Sep 24, 1986Paper

Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties

Brain Research
F C Tortella, J M Musacchio

Abstract

The non-opioid antitussives dextromethorphan and carbetapentane, the active ingredients of several over-the-counter cough suppressants, provide a dose-related protection against maximal electroshock seizures in rats. Both drugs, which bind with high affinity to the same site in the brain, potentiated the effects of the prototypic antiepileptic drug diphenylhydantoin. We propose that these novel anticonvulsant drugs may represent potentially useful therapeutic agents for the treatment of some forms of epilepsy, either alone or in combination with existing antiepileptic drugs.

References

Jan 1, 1984·Cleveland Clinic Quarterly·R J PorterB G White
Jun 23, 1983·The New England Journal of Medicine·A V Delgado-EscuetaG O Walsh
Sep 1, 1983·The New England Journal of Medicine·D L Schomer
Jan 1, 1983·Acta Neurologica Scandinavica. Supplementum·L Gram, K D Bentsen
Jun 1, 1984·Experimental Neurology·M Dragunow, G V Goddard
Aug 1, 1980·Toxicology and Applied Pharmacology·J W Barnhart

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Citations

Jun 1, 1988·Cellular and Molecular Neurobiology·J M Musacchio, M Klein
Nov 6, 2010·Archives of Pharmacal Research·Eun-Joo ShinHyoung-Chun Kim
Oct 11, 1988·European Journal of Pharmacology·F C TortellaJ M Musacchio
Jun 22, 1988·European Journal of Pharmacology·J W FerkanyM J Pontecorvo
Jul 18, 1989·European Journal of Pharmacology·A G Chapman, B S Meldrum
Dec 1, 1989·Trends in Pharmacological Sciences·F C TortellaN G Bowery
Apr 12, 1988·Neuroscience Letters·H R FeeserD A Prince
Jan 1, 1991·General Pharmacology·S SagratellaA S de Carolis
Mar 1, 1991·Brain Research Bulletin·M J PontecorvoJ W Ferkany
Jan 1, 1995·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M GavendG Baragatti
Oct 1, 1991·Epilepsy Research·R S Fisher
Oct 1, 1996·General Pharmacology·G Tunnicliff
Feb 1, 1990·Journal of Neurosurgery·R L HayesH F Young
Mar 19, 2003·British Journal of Pharmacology·Hui-Hung WangChieh-Fu Chen
Nov 8, 2011·Epilepsy & Behavior : E&B·Mehdi Ghasemi, Steven C Schachter
Sep 10, 2014·Toxicology·Lily RavehBen Avi Weissman
May 25, 2011·Journal of Pharmacological Sciences·Eun-Joo ShinHyoung-Chun Kim
May 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J H Swan, B S Meldrum
Sep 1, 1988·Stroke; a Journal of Cerebral Circulation·G K SteinbergT Gross
Sep 1, 1989·Stroke; a Journal of Cerebral Circulation·G K SteinbergS R Zarnegar
Aug 25, 2005·Journal of Separation Science·Natale Alfredo SantagatiGiuseppe Ronsisvalle
Feb 1, 1995·Canadian Journal of Physiology and Pharmacology·J A PrasadS Lemaire
May 14, 2004·The Journal of Pharmacology and Experimental Therapeutics·A J WilliamsJ A Hartings

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