DHA-1-producing Klebsiella pneumoniae in a teaching hospital in the Czech Republic

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Joanna EmpelMarek Gniadkowski

Abstract

Thirty-eight AmpC-producing Klebsiella pneumoniae isolates identified from January to October 2006 in a large teaching hospital in the Czech Republic were analyzed. The AmpC cephalosporinase was identified as DHA-1, encoded by a plasmid-located complex class 1 integron, previously observed in a K. pneumoniae isolate from the Parisian region. The DHA-1 expression was inducible, and although in two isolates with higher resistance, the induction effect was masked at the phenotypic level. All of the isolates belonged to the international K. pneumoniae clone sequence type 11, split into two disseminated pulsed-field gel electrophoresis types. This is the first report on enterobacteriaceae with acquired AmpCs in the Czech Republic and possibly the first description of organisms with DHA-1 in the Central and Eastern Europe.

References

Sep 1, 1990·Infection·A BauernfeindS Schweighart
Dec 26, 2001·Antimicrobial Agents and Chemotherapy·Alain PhilipponGeorge A Jacoby
May 31, 2002·Journal of Clinical Microbiology·F Javier Pérez-Pérez, Nancy D Hanson
Apr 15, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J S OxfordR Lambkin
Jan 27, 2004·Antimicrobial Agents and Chemotherapy·M AlvarezG A Jacoby
Jun 7, 2005·Journal of Microbiological Methods·Alessandra CarattoliE John Threlfall
Aug 6, 2005·Journal of Clinical Microbiology·Laure DiancourtSylvain Brisse
May 17, 2006·International Journal of Antimicrobial Agents·Tetsuro MurataniTetsuro Matsumoto
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L DrieuxV Jarlier
Apr 10, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C RocheB Crowley
May 2, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H DingX Shen
Jan 13, 2009·Clinical Microbiology Reviews·George A Jacoby
Jun 16, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C MataF Navarro
Jul 3, 2009·International Journal of Antimicrobial Agents·Hassen IabadeneGuillaume Arlet

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Citations

Sep 8, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E MiróF Navarro
Nov 16, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·J HrabákUNKNOWN Czech Participants of European Antimicrobial Resistance Surveillance Network
Jul 24, 2014·Diagnostic Microbiology and Infectious Disease·Fabrice CompainCharlotte Verdet
Jan 1, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Fátima Galán-SánchezManuel Rodríguez-Iglesias
Feb 26, 2014·Antimicrobial Agents and Chemotherapy·C C PapagiannitsisJ Hrabak

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Methods Mentioned

BETA
Electrophoresis
PCR

Software Mentioned

Lasergene

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