Di (2-ethylhexyl) phthalate (DEHP)-induced hepatotoxicity in quails (Coturnix japonica) via triggering nuclear xenobiotic receptors and modulating cytochrome P450 systems

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Ying-Zhi ZhangJin-Long Li

Abstract

Di (2-ethylhexyl) phthalate (DEHP) is a widely distributed pollutant that is of great concern due to its negative health effects. However, whether DEHP exposure causes liver toxicity in birds remains unclear. To clarify the potential hepatotoxicity of DEHP, quails were exposed to 0, 250, 500 and 1000 mg/kg BW/day DEHP by gavage treatment for 45 days. The livers of DEHP-exposed quails showed histomorphological changes. DEHP exposure induced a significant increase in cytochrome P450 enzyme system (CYP450s) activity (including aniline-4-hydroxylase (AH), aminopyrine N-demethylase (APND), erythromycin N-demethylase (ERND) and NADPH-cytochrome C reductase (NCR)) and in the contents of total cytochrome P450 (CYP450) and cytochrome b5 (Cyt b5) in quail liver. DEHP exposure also influenced the expression of nuclear xenobiotic receptors (NXRs) and CYP450 isoforms in the liver. The results suggested that DEHP-induced hepatotoxicity in quail liver is associated with activation of the NXRs pathway responses and disruption of CYP450s homeostasis. This study will help to further elucidate DEHP exposure-induced liver toxicity in quails.

Citations

May 31, 2020·International Journal of Environmental Research and Public Health·Chun-Ya LeeYi-Jen Liao
Jan 16, 2021·Environmental Science and Pollution Research International·Rui-Jing LiuChun-Hong Liu
Feb 19, 2021·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Ke ZhangLin Li
May 24, 2021·Environmental Science and Pollution Research International·Hamidreza Mohammadi, Sorour Ashari
Mar 25, 2019·Environmental Science & Technology·Scott CoffinDaniel Schlenk
Jan 24, 2020·Journal of Agricultural and Food Chemistry·Yi ZhaoJinlong Li
Oct 21, 2021·Journal of Agricultural and Food Chemistry·Mu-Zi LiJin-Long Li
Jan 16, 2022·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hao ZhangJin-Long Li

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