Di(2-Ethylhexyl) Phthalate Exposure During Prenatal Development Causes Adverse Transgenerational Effects on Female Fertility in Mice.

Toxicological Sciences : an Official Journal of the Society of Toxicology
Saniya RattanJodi A Flaws

Abstract

Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental toxicant and endocrine disrupting chemical, but little is known about its effects on female reproduction. Thus, we tested the hypothesis that prenatal exposure to DEHP accelerates the onset of puberty, disrupts estrous cyclicity, disrupts birth outcomes, and reduces fertility in the F1, F2, and F3 generations of female mice. Pregnant CD-1 mice were orally dosed with corn oil (vehicle control) or DEHP (20 and 200 µg/kg/day and 500 and 750 mg/kg/day) from gestation day 10.5 until birth. F1 females were mated with untreated males to obtain the F2 generation. F2 females were mated with untreated males to produce the F3 generation. In all generations, the onset of puberty, estrous cyclicity, select birth outcomes, and fertility-related indices were evaluated. In the F1 generation, prenatal DEHP exposure (200 µg/kg/day) accelerated the onset of puberty, it (200 µg and 500 mg/kg/day) disrupted estrous cyclicity, and it (20 and 200 µg/kg/day) decreased fertility-related indices. In the F2 generation, ancestral DEHP exposure (500 mg/kg/day) accelerated the onset of puberty, it (20 and 200 µg/kg/day) disrupted estrous cyclicity, it (20 µg and 500 mg/kg/day) increased litter ...Continue Reading

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Citations

Sep 29, 2018·Basic & Clinical Pharmacology & Toxicology·Jerrold J Heindel
Jan 11, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mingxin ShiKanako Hayashi
May 12, 2019·Biology of Reproduction·Saniya Rattan, Jodi A Flaws
Mar 18, 2020·International Journal of Molecular Sciences·Andressa GonsioroskiJodi A Flaws
Dec 9, 2020·Nature Reviews. Endocrinology·David Lopez-RodriguezAnne-Simone Parent
Nov 21, 2020·Environmental Epigenetics·Camille AkemannTracie R Baker
Jan 24, 2020·Journal of Agricultural and Food Chemistry·Yi ZhaoJinlong Li

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