Diabetes--a man made disease

Medical Hypotheses
R B Elliott

Abstract

The recent increase in both forms of diabetes must be caused by a modern change in the environment. Candidate agents must satisfy at least three criteria. Firstly, the agent must have increased in the environment recently, secondly that it causes diabetes in appropriate animal models, and thirdly that there is a plausible diabetogenic mechanism. Modern food processing can produce glycation end products, oxidised ascorbic acid and lipoic acid, all of which may cause diabetes. Infant formula in particular has high levels of glycation products, and added ascorbic acid. A casomorphin released from A1 beta-casein (but not the A2 variant) can become glycated and have adverse immune effects. Food processing and additives can be posited as a man made cause of the increase in both forms of diabetes. This hypothesis does not exclude other environmental agents which meet the above three criteria.

References

May 19, 1990·BMJ : British Medical Journal·G G DahlquistS G Wall
Feb 1, 1994·Free Radical Research·B C ScottB Halliwell
Jul 1, 1994·Diabetologia·H Kolb, R B Elliott
Jun 28, 2003·Neurotoxicity Research·V Prakash ReddyMark A Smith
Dec 18, 2003·Annals of the New York Academy of Sciences·M A MyersP Z Zimmet
Apr 1, 2004·Endocrinology and Metabolism Clinics of North America·Outi Vaarala
May 28, 2004·Toxicology and Applied Pharmacology·Chin-Hsiao Tseng
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yali ChenKevan C Herold
Jun 21, 2005·Cellular Immunology·Christophe Filippi, Matthias von Herrath

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Citations

Dec 17, 2008·Lipids·Mikhail VyssotskiDawn Scott
Dec 23, 2008·Diabetes Research and Clinical Practice·Tony R Merriman

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