Diabetes aggravates acute pancreatitis and inhibits pancreas regeneration in mice.

Diabetologia
D ZechnerB Vollmar

Abstract

It is well established that acute pancreatitis often causes diabetes and that a high blood glucose level associated with pancreatitis is a marker of poor prognosis. The aim of this study was to evaluate if diabetes merely reflects the severity of pancreatitis or whether it can also aggravate the progression of this disease in a vicious circle. Reversible acute oedematous pancreatitis was induced in untreated and streptozotocin-treated diabetic mice by injection of cerulein. Progression of pancreatitis was studied by immunohistochemistry, ELISA and various other enzyme assays. The production of regenerating islet-derived 3β (REG3β) was determined by western blot and immunohistochemistry. While cerulein treatment in non-diabetic mice resulted in acute pancreatitis followed by regeneration of the pancreas within 7 days, diabetes aggravated pancreatitis, inhibited the regeneration of the exocrine tissue and led to strong atrophy of the pancreas. The aggravation of pancreatitis by diabetes was characterised by decreased production of the anti-inflammatory protein REG3β, increased inflammation, augmented oedema formation and increased cell death during the acute phase of pancreatitis (p < 0.05). During the regenerative phase, diabete...Continue Reading

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Citations

Jun 7, 2012·European Journal of Gastroenterology & Hepatology·Yuzheng XueZhaoshen Li
Nov 18, 2014·International Journal of Experimental Pathology·Dietmar ZechnerBrigitte Vollmar
Jan 15, 2015·The Journal of Small Animal Practice·L J Davison
Apr 11, 2014·Experimental Biology and Medicine·Dietmar ZechnerBrigitte Vollmar
Jul 6, 2014·The Journal of Biological Chemistry·Aysha SamadJason I E Bruce
Aug 2, 2018·World Journal of Gastroenterology : WJG·Franz-Tassilo Müller-GraffDietmar Zechner
Nov 22, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Xinghao JiangGuiping Ren
Apr 24, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Hemanth K KandikattuAnil Mishra

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