Diabetes aggravates heat stress-induced blood-brain barrier breakdown, reduction in cerebral blood flow, edema formation, and brain pathology: possible neuroprotection with growth hormone

Annals of the New York Academy of Sciences
Dafin F MuresanuHari Shanker Sharma

Abstract

The possibility that diabetes influences the outcome of heat stress-induced brain pathology was examined in our experimental rat model. Because growth hormone (GH) deficiency is an important factor in diabetes, the possible neuroprotective role of GH supplements was also examined in diabetic rats following heat stress. Rats receiving streptozotocine once daily for three days (50 mg/kg, i.p.) and allowed to survive four weeks resulted in diabetes (blood glucose level 18 and 20 mMol/L) compared to controls (blood glucose 4-6 mMol/L). Control or diabetic rats when subjected to four hours' heat stress at 38 degrees C in a biological oxygen demand incubator (BOD) showed profound disruption of the blood-brain barrier (BBB), reduction in cerebral blood flow (CBF), brain edema formation, and cell injury. These effects were most pronounced in diabetic rats. Pretreatment with GH (50 microg/kg/min for 10 min before heat stress) significantly attenuated brain pathology in normal animals subjected to hyperthermia. On the other hand, almost a double dose of the growth hormone (80 to 120 microg/g/min for 10 min) is needed in diabetic rats to induce considerable neuroprotection following heat stress. These observations are the first to suggest...Continue Reading

References

Oct 1, 1976·Journal of the Neurological Sciences·E Melamed
Jan 1, 1987·Stroke; a Journal of Cerebral Circulation·R B DuckrowR W Brennan
Jun 20, 1998·Progress in Brain Research·H S SharmaJ Westman
Jun 20, 1998·Progress in Brain Research·H S SharmaF Nyberg
Mar 29, 2003·Brain Research·Pamela EspositoTheoharis C Theoharides
Sep 24, 2004·Experimental Cell Research·Tamotsu SomaNorimasa Sawada
Nov 2, 2004·Endocrine Journal·Minoru IrieKohji Shirai
Nov 29, 2005·Foot & Ankle International·Fabio BatistaCaio A S Nery
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jason D HuberKimberly A Houser
Nov 18, 2006·Neuroscience Letters·Brian T HawkinsRichard D Egleton
Jul 25, 2007·Progress in Brain Research·Hari Shanker Sharma
Dec 14, 2007·Annals of the New York Academy of Sciences·Hari Shanker Sharma
Dec 15, 2007·Metabolism: Clinical and Experimental·Maria Claudia Peixoto CenciMario Vaisman
Mar 4, 2008·Molecular Pain·Reddy M PabbidiLouis S Premkumar
Aug 5, 2008·Current Pharmaceutical Design·J D Huber
Feb 26, 2009·Endocrine Reviews·Niels Møller, Jens Otto Lunde Jørgensen
Apr 14, 2009·Neuroscience·E A Kiyatkin, H S Sharma

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Citations

Nov 6, 2001·Journal of Neuroimmunology·N ChenC S Reiss
Sep 6, 2014·Biologie aujourd'hui·Anna Bencsik
Oct 15, 2014·Expert Opinion on Drug Metabolism & Toxicology·Hari S SharmaAruna Sharma
Feb 24, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Karolina NiskaIwona Inkielewicz-Stepniak
Jan 19, 2012·Journal of the Neurological Sciences·Athanasios Chalkias, Theodoros Xanthos
Feb 12, 2014·Resuscitation·Athanasios ChalkiasTheodoros Xanthos
Oct 28, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Danni ZhengUNKNOWN INTERACT investigators
Apr 27, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ayman ElAli, Dirk M Hermann
Apr 13, 2019·Current Topics in Medicinal Chemistry·Niraj Kumar JhaRituraj Niranjan
Aug 16, 2019·Environmental Research·Joanna A RuszkiewiczMichael Aschner
Jan 21, 2021·International Journal of Molecular Sciences·So Yeong Cheon, Juhyun Song

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