PMID: 9427509Jan 14, 1998Paper

Diabetes and axotomy-induced deficits in retrograde axonal transport of nerve growth factor correlate with decreased levels of p75LNTR protein in lumbar dorsal root ganglia

Brain Research. Molecular Brain Research
J D DelcroixP Fernyhough

Abstract

The effect of sensory neurone axotomy on the level of retrograde axonal transport of nerve growth factor (NGF) was studied in the sciatic nerve of age-matched normal and 8-week streptozocin-diabetic rats. In normal rats a 10-day sciatic nerve crush induced a 41% decrease in transported NGF, however, axotomy of sensory neurones of diabetic rats did not significantly effect the already deficient levels of NGF undergoing retrograde transport. At first sight, this result indicated that transported NGF levels in the sciatic nerve of diabetic rats are at a residual level due to deficient availability of target-derived NGF. To confirm this, the relationship of the transported NGF to the level of sensory neurone expression of the NGF receptor proteins was analysed. Western blots of L4 and L5 dorsal root ganglia (DRG) homogenates revealed no effect of axotomy and/or diabetes on the levels of the 145-kDa tyrosine kinase form of trkA. However, the expression of p75LNTR protein in the intact DRG was reduced in diabetic compared with normal rats (56%; P < 0.01), and axotomy reduced the levels in the ipsilateral ganglia of normal but not diabetic rats - as seen for NGF axonal transport. Reductions in retrograde axonal transport of NGF in bot...Continue Reading

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Citations

Mar 20, 2003·Current Diabetes Reports·Nigel A Calcutt
Feb 20, 2003·Brain Research. Molecular Brain Research·Fang Cai, Cinda J Helke
May 22, 2003·Progress in Neurobiology·Hitoshi YasudaRyuichi Kikkawa
Feb 13, 1999·Progress in Neurobiology·M J Millan
Nov 19, 2003·Neuroscience Letters·Jean-Dominique DelcroixPaul Fernyhough
May 6, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·L T DiemelD R Tomlinson
Sep 28, 2010·Indian Journal of Pharmacology·A S Shaikh, R S Somani
Mar 2, 2006·European Journal of Pharmacology·Nigel A CalcuttAndrew P Mizisin
Mar 1, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sophie PezetStephen B McMahon
Mar 14, 2001·Journal of Neuropathology and Experimental Neurology·R E SchmidtE Escandon
Jan 1, 2010·Expert Review of Endocrinology & Metabolism·Douglas W Zochodne
Jul 12, 2008·Pharmacology & Therapeutics·James L EdwardsEva L Feldman

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