Abstract
We investigated whether the relationship between diabetes and all-cause and CVD-related mortality differed between women with and without breast cancer among a cohort drawn from the same source population. We interviewed 1,363 women newly diagnosed with breast cancer in 1996-1997, and 1,358 age-matched women without breast cancer, to assess history of physician-diagnosed diabetes. All-cause (n = 631) and CVD-specific mortality (n = 234) was determined by the National Death Index through 2009. We estimated multivariable-adjusted hazard ratios (HRs) for the rates of all-cause and CVD-specific mortality and, to account for competing causes of death, and subdistribution HRs (sHRs) for risk of CVD-related death. Among women with and without breast cancer, respectively, diabetes was associated with: all-cause mortality [HR (95% CI) 1.52 (1.13, 2.05) and 2.17 (1.46, 3.22)]; CVD-specific deaths [1.74 (1.06, 2.84) and 2.06 (1.11, 3.84)]; and risk of CVD-related death [sHR 1.36 (0.81, 2.27) and 1.79 (0.94, 3.40)]. Differences in effect estimates between women with and without breast cancer did not reach statistical significance (p-interaction > 0.10). We found that the positive association between a history of physician-diagnosed diabete...Continue Reading
References
Mar 1, 1979·Diabetes Care·W B Kannel, D L McGee
Sep 11, 2002·Breast Cancer Research and Treatment·Marilie D GammonG Iris Obrams
Sep 2, 2004·Journal of the National Cancer Institute·Catherine SchairerSusan S Devesa
Apr 18, 2007·Cancer Causes & Control : CCC·Thomas A SellersCeline M Vachon
Jul 31, 2007·Breast Cancer Research and Treatment·Lorraine L LipscombeJanet E Hux
Jan 28, 2010·Diabetes Care·Markku Laakso
Oct 26, 2010·Population Health Metrics·James P BoyleDavid F Williamson
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly S PeairsAntonio C Wolff
May 9, 2012·Journal of Clinical Epidemiology·Jody M JacksonKaren L Margolis
Jun 8, 2012·Cancer Causes & Control : CCC·Rebecca J ClevelandMarilie D Gammon
Aug 23, 2012·PloS One·Yurong ZhangLiwei Chen
Sep 28, 2012·American Journal of Epidemiology·Andrea L C SchneiderElizabeth Selvin
Feb 13, 2013·Circulation·Neha Jadeja Pagidipati, Thomas A Gaziano
Feb 19, 2013·Journal of Cancer Survivorship : Research and Practice·Kathryn E WeaverNoreen M Aziz
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Carol DeSantisAhmedin Jemal
Sep 28, 2014·Breast Cancer Research and Treatment·Juhua LuoKaren Margolis
Oct 15, 2014·ANZ Journal of Surgery·Yunhai ZhouJiazeng Xia
Nov 27, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anna H WuCheryl Vigen
Sep 29, 2015·Epidemiology·Patrick T BradshawMarilie D Gammon
Feb 10, 2016·Circulation·Peter C AustinJason P Fine
Nov 1, 2016·World Journal of Diabetes·Longjian LiuHoward J Eisen
Dec 21, 2016·Cancer Causes & Control : CCC·Marjory CharlotJulie R Palmer
May 16, 2017·Breast Cancer Research and Treatment·S A M GernaatH M Verkooijen
Feb 14, 2018·Circulation·Laxmi S MehtaUNKNOWN American Heart Association Cardiovascular Disease in Women and Special Populations Committee of the Council on Clinical Card
Mar 30, 2018·MMWR. Morbidity and Mortality Weekly Report·Kai McKeever BullardGiuseppina Imperatore
Oct 28, 2018·Breast Cancer Research and Treatment·Gertraud MaskarinecLoïc Le Marchand
Feb 8, 2020·JCO Global Oncology·Amanda J SheppardLoraine D Marrett