Diabetes and Cognitive Decline in Older Adults: The Ginkgo Evaluation of Memory Study

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Priya PaltaSherita Hill Golden

Abstract

Previous studies have shown that individuals with diabetes exhibit accelerated cognitive decline. However, methodological limitations have limited the quality of this evidence. Heterogeneity in study design, cognitive test administration, and methods of analysis of cognitive data have made it difficult to synthesize and translate findings to practice. We analyzed longitudinal data from the Ginkgo Evaluation of Memory Study to test our hypothesis that older adults with diabetes have greater test-specific and domain-specific cognitive declines compared to older adults without diabetes. Tests of memory, visuo-spatial construction, language, psychomotor speed, and executive function were administered. Test scores were standardized to z-scores and averaged to yield domain scores. Linear random effects models were used to compare baseline differences and changes over time in test and domain scores among individuals with and without diabetes. Among the 3,069 adults, aged 72-96 years, 9.3% reported diabetes. Over a median follow-up of 6.1 years, participants with diabetes exhibited greater baseline differences in a test of executive function (trail making test, Part B) and greater declines in a test of language (phonemic verbal fluency...Continue Reading

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Jan 30, 2018·Journal of Diabetes Investigation·Hiroyuki Umegaki
Jul 1, 2020·Terapevticheskiĭ arkhiv·E V SurkovaA V Naminov
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Oct 1, 2021·Journal of Gerontological Nursing·Erica Wilson
Oct 5, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marianne Chanti-KetterlYang Claire Yang

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