PMID: 3384189Jul 1, 1988Paper

Diabetes and diuretic-induced alterations in function of rat urinary bladder

Diabetes
E M KudlaczL J Wallace

Abstract

Studies were done to characterize the bladder dysfunction associated with diabetes mellitus and to distinguish between changes occurring from increased diuresis and autonomic neuropathy. Four experimental conditions were compared: control, 4-wk-streptozocin-induced diabetes, sucrose feeding (diuretic), and galactose feeding (diuretic and sugar alcohol). A 10-fold increase in urine output and 25-50% increases in bladder weight, protein content, and DNA content were observed in all noncontrol treatment groups. Compliance properties were studied by measuring the intravesicular pressure as the bladder was infused with buffer in vitro. All treated bladders exhibited a reduction in plateau pressure and an increase in fluid capacity. Thus, diuresis results in an increased bladder size, which correlates with an alteration of compliance properties. Nervous system control in anesthetized rats was examined by monitoring contractions as the bladder was infused with buffer. Three distinct patterns of response were observed: normal, diabetic, and diuretic (galactose and sucrose treatments). The difference between responses in diuretic and diabetic animals suggests the presence of a diabetes-induced alteration in nerve regulation of the bladd...Continue Reading

Citations

Jul 1, 1990·Journal of the Autonomic Nervous System·M Prosdocimi, M Paro
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Aug 1, 1997·Scandinavian Journal of Urology and Nephrology·O TorffvitA Mattiasson
Jan 28, 2014·International Neurourology Journal·Hyo Jeong SongJiyoung Kang
Jan 1, 1994·Diabetes Research and Clinical Practice·H ItohI Makino
Aug 2, 2006·Autonomic & Autacoid Pharmacology·L A StevensR Chess-Williams
Aug 1, 1991·The Journal of Urology·P A Longhurst, R M Levin

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