Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study.

Cardiovascular Diabetology
Haruhiko OsawaYutaka Kiyohara

Abstract

Resistin, secreted from adipocytes, causes insulin resistance in mice. The relationship between resistin and coronary artery disease is highly controversial, and the information regarding resistin and ischemic stroke is limited. In the present study, the association between serum resistin concentration and cardiovascular disease (CVD) was investigated in a general Japanese population. A total of 3,201 community-dwelling individuals aged 40 years or older (1,382 men and 1,819 women) were divided into quintiles of serum resistin, and the association between resistin and CVD was examined cross-sectionally. The combined effect of either diabetes or hypertension and high serum resistin was also assessed. Serum resistin was measured using ELISA. Compared to those without CVD, age- and sex-adjusted mean serum resistin concentrations were greater in subjects with CVD (p = 0.002) or ischemic stroke (p < 0.001), especially in those with lacunar and atherothrombotic infarction, but not elevated in subjects with hemorrhagic stroke or coronary heart disease. When analyzed by quintile of serum resistin concentration, the age- and sex-adjusted odds ratio (OR) for having CVD and ischemic stroke increased with quintile of serum resistin (p for ...Continue Reading

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Citations

Dec 31, 2011·Environmental Health and Preventive Medicine·Terumi KogawaIkuo Kashiwakura
Aug 31, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Aya HigashiyamaYoshihiro Miyamoto
Oct 13, 2010·Cardiovascular Diabetology·Enrique Z Fisman, Alexander Tenenbaum
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Apr 18, 2015·Journal of Diabetes Research·Antonino TuttolomondoAntonio Pinto
Mar 27, 2015·PloS One·Lorena Ortega MorenoClaudia Menzaghi
Aug 29, 2017·Topics in Stroke Rehabilitation·Edi PerovicAna-Maria Simundic
Dec 19, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alessandro P DelitalaGiovanni M Pes
Jun 18, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Karina GasbarrinoStella S Daskalopoulou
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Nov 18, 2018·Diabetes/metabolism Research and Reviews·Agnieszka Kapłon-CieślickaKrzysztof J Filipiak
Aug 28, 2021·International Journal of Molecular Sciences·Sebastian AndoneRodica Balasa

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Methods Mentioned

BETA
coronary artery bypass
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

SAS

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