Diabetes and Menopause

Current Diabetes Reports
Carrie A Karvonen-GutierrezCatherine Kim

Abstract

During menopause, women's body composition, sex hormone profile, and metabolic profile may change dramatically. In this review, we summarize studies examining whether the menopausal transition and physiologic factors characterizing the transition are associated with increased risk of diabetes. We review the evidence for estrogen therapy and diabetes risk and studies examining the relationship between diabetes and menarche, which represents an extension of the reproductive life span at the opposite end of the age spectrum. Although studied less extensively, the presence of type 1 or type 2 diabetes may increase the risk of ovarian failure, and we review this literature. In conclusion, we note that the evidence linking menopausal sex hormone changes with increased diabetes risk is weak, although rapid changes as observed with oophorectomy may increase risk. Further studies should investigate the contradictory effects of estrogen therapy upon hepatic and glucose metabolism in mid-life women.

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Citations

Mar 23, 2017·Endocrinology·Deborah CleggVictoria J Vieira-Potter
Dec 28, 2016·Experimental Animals·Chunhua YinHongping Chen
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Jan 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Catherine KimWilliam C Knowler
Mar 22, 2019·The Journal of Clinical Endocrinology and Metabolism·Jiajia JiangYan He
May 28, 2020·International Journal of Molecular Sciences·Elena S GardiniUlrike Ehlert
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Feb 28, 2021·Medicina clínica·María Dolores García de Lucas, Ana Isabel Jiménez Millán
Mar 16, 2021·Climacteric : the Journal of the International Menopause Society·S Bansal, K Chopra

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