Diabetes and microvascular pathophysiology: role of epidermal growth factor receptor tyrosine kinase.

Diabetes/metabolism Research and Reviews
Khalid Matrougui

Abstract

Type 2 diabetes is responsible for the increased prevalence of ischaemic heart disease, generally related to coronary artery disease, which is associated with increased morbidity and death in diabetic patients. Epidermal growth factor receptor (EGFR) tyrosine kinase, one of the many factors involved in cell growth and migration, has been shown to be key element in the development of microvessel myogenic tone. In a recent study, we have shown that microvascular dysfunction in type 2 diabetes is dependent on the exacerbation of the EGFR tyrosine kinase phosphorylation. Thus, further elucidation of this EGFR transactivation and down stream signalling will offer a new direction to investigate the mechanism of microvascular dysfunction responsible for heart disease that occurs in type 2 diabetes. In this review, we discuss the link between the EGFR transactivation and microvascular dysfunction that occurs in type 2 diabetes.

References

Apr 1, 1990·Physiological Reviews·J I Hoffman, J A Spaan
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·G S Kassab, S Molloi
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zsolt BagiGabor Kaley
Jun 28, 2003·The Journal of Biological Chemistry·Atsushi Konishi, Bradford C Berk
Nov 5, 2004·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Azra Mahmud, John Feely
Nov 14, 2008·Journal of Cellular Physiology·Marlon R Schneider, Eckhard Wolf
Apr 4, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Souad BelmadaniWilliam M Chilian

❮ Previous
Next ❯

Citations

Jul 3, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ran KleinRobert A deKemp
Aug 27, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Tali SharirDaniel S Berman
Oct 18, 2013·International Journal of Molecular Sciences·Nader MakkiFrancis J Miller
Apr 14, 2015·Journal of Molecular and Cellular Cardiology·Zheng Xu, Lu Cai
Jan 3, 2012·Analytical Chemistry·Chung-Liang WangKuo Chu Hwang
Jan 4, 2017·The International Journal of Biochemistry & Cell Biology·Melissa E ReicheltJohn P Headrick
Jul 10, 2012·Journal of Diabetes Science and Technology·H James HarwoodJanice D Wagner
Oct 19, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carmen GalanJuan A Rosado
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Dec 31, 2017·Pflügers Archiv : European journal of physiology·Vishal MaliSouad Belmadani
Oct 18, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Steven D BrooksPaul D Chantler
Feb 13, 2021·Frontiers in Pharmacology·Lili ShengShougang Zhuang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.