Abstract
Angiotensin II, the effector peptide of the renin-angiotensin system (RAS), has potent growth factor properties in a variety of organs. In the retina, a complete RAS exists, with components residing in the vasculature, neurons and glia. There is increasing interest in a pathogenetic role for angiotensin II in ischaemic retinopathies such as diabetic retinopathy and retinopathy of prematurity. In these situations, the retinal RAS becomes activated and stimulates growth factors such as vascular endothelial growth factor, which contribute to vascular leakage, pericyte migration, angiogenesis and fibrosis. Blockade of the RAS, with either angiotensin-converting enzyme (ACE) inhibitors or antagonists selective for angiotensin type 1 (AT1) and angiotensin type 2 (AT2) receptors, attenuates many of the vascular abnormalities that develop in diabetic retinopathy and retinopathy of prematurity. Eagerly awaited are the findings of the Diabetic Retinopathy Candesartan Trial (DIRECT), evaluating the effects of AT1 receptor antagonism in patients with different stages of diabetic retinopathy. This review examines the role of the RAS in diabetic retinopathy and retinopathy of prematurity, and the potential of RAS blockade as a treatment stra...Continue Reading
Citations
Sep 19, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Erica L FletcherJennifer L Wilkinson-Berka
Aug 19, 2007·Diabetes, Obesity & Metabolism·G MathurG Davis
Dec 7, 2011·Experimental Diabetes Research·Yoko OzawaKazuo Tsubota
Sep 20, 2008·Physical Therapy·W Todd Cade
Aug 26, 2014·Neurobiology of Disease·R P HulseL F Donaldson
Jan 10, 2016·Placenta·Sarah J DelforceKirsty G Pringle
Dec 18, 2015·Experimental Eye Research·Sayon RoySumon Roy
Apr 6, 2016·European Journal of Pharmacology·Olaf Strauß
Jun 2, 2009·Neurobiology of Disease·Lucia GaddiniFlavia Pricci
Sep 30, 2016·PloS One·Rita de Cassia BianchiGuilherme Mourão
Aug 21, 2015·Brazilian Journal of Biology = Revista Brasleira De Biologia·M B Vecchi, M A S Alves
Sep 23, 2008·Pharmacology & Therapeutics·Emma S JonesRobert E Widdop
May 9, 2015·PloS One·Caroline LeuchtenbergerGuilherme Mourão
Sep 25, 2014·Western Journal of Nursing Research·Li-Qin XieJun Zhou
Oct 6, 2016·Diabetologia·Nadine ReichhartAntonia M Joussen
Jul 18, 2017·Diabetologia·Valli VelayuthamKim C Donaghue
Oct 27, 2007·Current Eye Research·Jin-Zhong ZhangTimothy S Kern
Apr 6, 2016·Current Opinion in Ophthalmology·Barbara LorberKeith R Martin
Mar 17, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Nimish K AcharyaRobert G Nagele
Aug 15, 2020·Scientific Reports·Xiayu XuBin Gao
Oct 18, 2019·Experimental Eye Research·Nadine ReichhartOlaf Strauß
Jul 22, 2021·European Journal of Ophthalmology·Meng LiJin Yuan
May 20, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Randa S Eshaq, Norman R Harris