Diabetes and risk of cancer incidence: results from a population-based cohort study in northern Italy

BMC Cancer
Paola BallotariPaolo Giorgi Rossi

Abstract

Aim of this study was to compare cancer incidence in populations with and without diabetes by cancer site. Furthermore, we aimed at comparing excess risk of cancer according to diabetes type, diabetes duration and treatment, the latter as regards Type 2 diabetes. By use of the Reggio Emilia diabetes registry we classified the resident population aged 20-84 at December 31st 2009 into two groups: with and without diabetes. By linking with the cancer registry we calculated the 2010-2013 cancer incidence in both groups. The incidence rate ratios (IRR) by cancer site, type of diabetes, diabetes duration, and as concerns Type 2 diabetes, by treatment regimen were computed using Poisson regression model and non-diabetic group as reference. The cohort included 383,799 subjects without diabetes and 23,358 with diabetes. During follow-up, we identified 1464 cancer cases in subjects with diabetes and 9858 in the remaining population. Overall cancer incidence was higher in subjects with diabetes than in those without diabetes (IRR = 1.22, 95%CI 1.15-1.29), with similar results focusing on subjects with at least 2-year diabetes duration. Cancer sites driving overall increased risk were liver, pancreas, Colon rectum, and bladder in both sexe...Continue Reading

References

Oct 14, 2004·Gastroenterology·Yu-Xiao YangJames D Lewis
May 12, 2005·British Journal of Cancer·R HuxleyM Woodward
Nov 17, 2005·Journal of the National Cancer Institute·Susanna C LarssonAlicja Wolk
Mar 11, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hashem B El-SeragFariba Javadi
Oct 6, 2006·Diabetologia·S C LarssonA Wolk
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jocelyn S Kasper, Edward Giovannucci
Apr 3, 2007·International Journal of Cancer. Journal International Du Cancer·Susanna C LarssonAlicja Wolk
Jul 1, 2010·Diabetes Care·Edward GiovannucciDouglas Yee
Oct 16, 2010·Cancer Prevention Research·Andrea DecensiSara Gandini
Sep 1, 2011·Diabetes Research and Clinical Practice·Emmanouil M Pagkalos
Apr 6, 2012·Diabetologia·J A JohnsonUNKNOWN Diabetes and Cancer Research Consortium
Dec 29, 2013·Diabetes Research and Clinical Practice·Paola BallotariPaolo Giorgi Rossi
Mar 19, 2014·Diabetes Research and Clinical Practice·L GuariguataJ E Shaw
Aug 27, 2014·Current Diabetes Reports·Bendix CarstensenSøren Friis
Oct 29, 2015·The New England Journal of Medicine·Mauro TancrediMarcus Lind
Mar 1, 2016·Diabetologia·Bendix CarstensenUNKNOWN Diabetes and Cancer Research Consortium

❮ Previous
Next ❯

Citations

Feb 5, 2019·Cardiovascular Research·Wouter C Meijers, Rudolf A de Boer
Jul 10, 2019·Expert Review of Anticancer Therapy·Margherita PizzatoCarlo La Vecchia
Jul 31, 2019·SAGE Open Medicine·Mohsin Hk RoshanNikolai P Pace
Jul 25, 2019·The Cancer Journal·Rajeev Sharma
Jul 20, 2019·European Journal of Heart Failure·Rudolf A de BoerDirk J van Veldhuisen
Nov 7, 2019·Current Diabetes Reviews·Ronald B Brown
Feb 10, 2021·Deutsches Ärzteblatt International·Yvonne HuberJörn M Schattenberg
May 28, 2021·Toxicology Mechanisms and Methods·Pınar Koroglu-AydınRefiye Yanardag
Jun 29, 2021·Current Heart Failure Reports·Alessandra CuomoFlora Pirozzi
Jul 3, 2021·International Journal of Molecular Sciences·Anna GabryanczykAgnieszka Śliwińska
Oct 4, 2021·Prostate Cancer and Prostatic Diseases·Rocío Barrios-RodríguezJosé Juan Jiménez-Moleón
Nov 13, 2021·Problemy e̊ndokrinologii·E M FrantsiyantsI M Kotieva
Jan 27, 2022·Journal of Veterinary Internal Medicine·Sindumani A Manoharan, Rebecka S Hess

❮ Previous
Next ❯

Software Mentioned

STATA

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Diabetes Research and Clinical Practice
Paola BallotariPaolo Giorgi Rossi
International Journal of Cancer. Journal International Du Cancer
M McCredieJ M Ford
National Cancer Institute Monograph
Y T Gao
© 2022 Meta ULC. All rights reserved