PMID: 8611359Feb 1, 1996Paper

Diabetes as a complication of tacrolimus (FK506) in pediatric renal transplant patients

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
S FurthB Fivush

Abstract

Three cases of insulin-requiring diabetes mellitus associated with tacrolimus (FK506) therapy in pediatric renal transplant patients are presented. New-onset diabetes mellitus has been reported with tacrolimus therapy post liver and kidney transplants in up to 12% of adult patients, but is thought to be rare in pediatrics. Although insulin requirement with tacrolimus therapy has been occasionally reported in adolescent patients post liver transplant, only a single case in a pediatric kidney transplant recipient has been previously documented. These cases illustrate the significant diabetogenic effect of tacrolimus in pediatric renal transplant patients. As the use of tacrolimus becomes more prevalent in pediatric kidney transplantation, pediatric nephrologists should be aware of this potential complication.

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Citations

Apr 9, 1998·Transplantation Proceedings·M D BrendelR G Bretzel
Dec 5, 1998·Transplantation Proceedings·B L GohS Y Tan
Feb 28, 2002·Pediatric Emergency Care·Reza KeshavarzCameron Hassani
Mar 30, 1999·Transplantation·R ShapiroT E Starzl
Apr 14, 2000·Current Opinion in Pediatrics·T E Nevins
Jun 5, 2012·Indian Journal of Pediatrics·Sumantra SarkarAnjan Kumar Das
Oct 19, 2011·Pediatric Transplantation·Belde Kasap
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Andrew D BostomRussell H Wiesner
Oct 3, 2006·Current Opinion in Anaesthesiology·S D Kelley, G A Gregory
Jun 1, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G FillerB Hocher
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Quanxing WangXiao-Kang Li
Jul 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Eba H HathoutLeonard L Bailey

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