Diabetes as a coronary artery disease risk equivalent: before a change of paradigm?

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
Christoph H SaelyHeinz Drexel

Abstract

Current guidelines consider diabetes per se as a coronary artery disease (CAD) risk equivalent. We aimed at investigating the contribution of baseline coronary atherosclerosis to the risk of diabetic patients for future vascular events. Prospective cohort study. Vascular events were recorded over 4 years in 750 consecutive patients undergoing coronary angiography for the evaluation of stable CAD. From our patients, 244 had neither type 2 diabetes (T2DM) nor significant CAD (i.e. coronary stenoses >or=50%) at the baseline angiography, 50 had T2DM but not significant CAD, 342 did not have T2DM but had significant CAD, and 114 had both T2DM and significant CAD. Nondiabetic patients without significant CAD had an event rate of 9.0%. The event rate was similar in T2DM patients without significant CAD (8.0%, P = 0.951), but higher in nondiabetic patients with significant CAD (24.9%, P<0.001). Patients with T2DM and significant CAD had the highest event rate (43.0%). Importantly, T2DM patients without significant CAD had a significantly lower event rate than nondiabetic patients with significant CAD (P = 0.008). T2DM per se is not a CAD risk equivalent. Moderate-risk diabetic patients without significant CAD and very high-risk diabeti...Continue Reading

References

Dec 29, 1998·The New England Journal of Medicine·L A Simons, J Simons
Feb 15, 2001·Archives of Internal Medicine·P A LotufoJ E Manson
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Feb 6, 2004·Circulation·Chong Do LeeUNKNOWN Atherosclerosis Risk in Communities (ARIC) Study Investigators
Jul 14, 2004·Archives of Internal Medicine·Olga VaccaroUNKNOWN Multiple Risk Factor Intervention Trial Research Group
Mar 2, 2005·Archives of Internal Medicine·Sundar NatarajanStuart R Lipsitz
Apr 21, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Anette E BuykenGerd Assmann
Apr 9, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Matteo AnselminoUNKNOWN Euro Heart Survey Investigators
Oct 3, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Monique A M Jacobs-van der BruggenCaroline A Baan
Nov 11, 2008·JAMA : the Journal of the American Medical Association·Hisao OgawaUNKNOWN Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial Investigators
Feb 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·U BulugahapitiyaI Idris
Mar 17, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Kornelia KotsevaUNKNOWN EUROASPIRE Study Group
Mar 24, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Christoph LangerDieter Horstkotte
May 14, 2009·Diabetes Care·Monique A M Jacobs-van der BruggenCaroline A Baan
Apr 26, 2011·Diabetes Care·Sadanori OkadaUNKNOWN Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes Trial Investigators

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Citations

May 20, 2011·The Journal of Clinical Endocrinology and Metabolism·Jane E B Reusch, Cecilia C Low Wang
Mar 6, 2013·Vascular Health and Risk Management·Juergen R SchaeferKurt Bestehorn
Nov 24, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Wanda AcampaAlberto Cuocolo
Jan 10, 2013·Current Cardiology Reports·Johanna Kuusisto, Markku Laakso
May 25, 2013·Vascular Pharmacology·Christoph H Saely, Heinz Drexel
Apr 17, 2012·European Journal of Preventive Cardiology·Markus ZeppetzauerChristoph H Saely
Feb 22, 2012·European Journal of Preventive Cardiology·Yu KataokaStephen J Nicholls
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Alessandro FilippiGiampiero Mazzaglia
May 26, 2012·Stroke; a Journal of Cerebral Circulation·Daniel T LacklandUNKNOWN Council on Quality of Care and Outcomes Research
Feb 5, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Søren GullaksenPer Løgstrup Poulsen
Aug 15, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wanda AcampaAlberto Cuocolo
Dec 7, 2011·Expert Review of Clinical Pharmacology·Yehuda HandelsmanJulio Rosenstock

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Methods Mentioned

BETA
coronary artery bypass
coronary artery imaging

Software Mentioned

SPSS

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