Diabetes Associated Metabolomic Perturbations in NOD Mice

Metabolomics : Official Journal of the Metabolomic Society
Dmitry GrapovManami Hara

Abstract

Non-obese diabetic (NOD) mice are a widely-used model oftype1 diabetes (T1D). However, not all animals develop overt diabetes. This study examined the circulating metabolomic profiles of NOD mice progressing or not progressing to T1D. Total beta-cell mass was quantified in the intact pancreas using transgenic NOD mice expressinggreen fluorescent protein under the control of mouse insulin I promoter.While both progressor and non-progressor animals displayed lymphocyte infiltration and endoplasmic reticulum stress in the pancreas tissue;overt T1D did not develop until animals lost ~70% of the total beta-cell mass.Gas chromatography time of flight mass spectrometry (GC-TOF) was used to measure >470 circulating metabolites in male and female progressor and non-progressor animals (n=76) across a wide range of ages (neonates to >40-wk).Statistical and multivariate analyses were used to identify age and sex independent metabolic markers which best differentiated progressor and non-progressor animals' metabolic profiles. Key T1D-associated perturbations were related with: (1) increased plasma glucose and reduced 1,5-anhydroglucitol markers of glycemic control; (2) increased allantoin, gluconic acid and nitric oxide-derived saccharic ac...Continue Reading

References

Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H KawasakiK Takeshita
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·S OyadomariM Mori
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
Oct 9, 2004·The Journal of Biological Chemistry·Monique R HeitmeierTimothy J Maziasz
Dec 18, 2007·Journal of Cellular and Molecular Medicine·C HolohanA Samali
Feb 14, 2008·The Plant Journal : for Cell and Molecular Biology·Oliver FiehnBasil Nikolau
Oct 31, 2008·Diabetes·Eitan AkiravKevan C Herold
Jan 31, 2009·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Robert Castelo, Alberto Roverato
Apr 21, 2009·Biotechnology Advances·Sandip B BankarLaxmi Ananthanarayan
Jun 26, 2009·The American Journal of Clinical Nutrition·Dionysia KalogeropoulouFrank Q Nuttall
Oct 8, 2009·American Journal of Physiology. Endocrinology and Metabolism·German KilimnikManami Hara
Nov 7, 2009·PloS One·Kevin MillerManami Hara
Jan 12, 2010·Diabetologia·R GiananiG S Eisenbarth
Jun 15, 2010·Apoptosis : an International Journal on Programmed Cell Death·S R SampsonS Frankel
Jun 16, 2010·Annals of Internal Medicine·David C ZiemerLawrence S Phillips
Jul 8, 2010·Islets·Abraham KimManami Hara
Mar 23, 2011·Nature Medicine·Thomas J WangRobert E Gerszten
Jul 30, 2011·The Journal of Small Animal Practice·E Vettorato, S Bacco
Jan 1, 2009·Advances and Applications in Bioinformatics and Chemistry : AABC·Giuseppe PalermoHans-Dieter Zucht
Sep 22, 2011·Journal of Cheminformatics·Evan E BoltonStephen H Bryant
Oct 11, 2011·Amino Acids·María M AdevaCristóbal Donapetry
Nov 3, 2011·PLoS Computational Biology·Marko Sysi-AhoMatej Orešič
Nov 15, 2011·Nucleic Acids Research·Minoru KanehisaMao Tanabe
Jan 31, 2012·Carbohydrate Research·Tyler N SmithDonald E Kiely
Apr 20, 2012·PloS One·Rasmus MadsenKristina Lejon
Jun 2, 2012·Islets·German KilimnikManami Hara
Jun 8, 2012·Cold Spring Harbor Perspectives in Medicine·Jasmin Lebastchi, Kevan C Herold
Aug 10, 2012·Diabetes Care·Stephen P JuraschekElizabeth Selvin

❮ Previous
Next ❯

Citations

Feb 2, 2016·Diabetes & Metabolism·M HaraL H Philipson
Oct 16, 2015·Electrophoresis·Biswapriya B Misra, Justin J J van der Hooft
Jan 30, 2016·Diabetes·Liyan ChenTien Yin Wong
Apr 8, 2015·Bioinformatics·Dmitry GrapovOliver Fiehn
Oct 27, 2016·Nature Microbiology·Alexandra E LivanosMartin J Blaser
Sep 24, 2015·Biomarker Insights·Kwanjeera WanichthanarakDmitry Grapov
Feb 6, 2020·Bioscience, Biotechnology, and Biochemistry·Atsushi ToyodaEiichi Inoue
May 20, 2020·Metabolites·Egon Taalberg, Kalle Kilk
Oct 1, 2015·Pediatric Diabetes·Brigitte I Frohnert, Marian J Rewers
Aug 9, 2020·Cell Transplantation·Virginia R AldrichMidhat H Abdulreda
Feb 7, 2015·Cancer Prevention Research·William R WikoffSuzanne Miyamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2022 Meta ULC. All rights reserved