Diabetes due to exocrine pancreatic disease--a review of patients attending a hospital-based diabetes clinic

QJM : Monthly Journal of the Association of Physicians
S PriceJ C Alcolado

Abstract

Diabetes secondary to underlying exocrine pancreatic disease is a specific, but heterogeneous, type of diabetes mellitus. Studies such as UKPDS and DCTT excluded patients with pancreatic diabetes, so there is a paucity of evidence regarding best clinical practice in this group. To characterize the clinical features of patients with diabetes secondary to underlying pancreatic disease attending general diabetes clinics in a single hospital. A cross-sectional observational cohort study, identifying patients with pancreatic diabetes from clinic letters and medical notes at the University Hospital of Wales, Cardiff, UK. The notes of 38 patients with pancreatic diabetes were reviewed. Of these, six had pancreatic malignancy and the remainder had a range of benign disorders. The majority (29/38) had diabetes diagnosed at or shortly after the pancreatic diagnosis was made. There was a lack of consistency regarding initial hypoglycaemic therapy, with metformin alone being the most common initial therapy, but with 30/38 taking insulin within 12 months of diagnosis. Similarly, a broad range of insulin regimens were employed with twice daily pre-mixed insulin being most prevalent. Sixty-three percent of patients were prescribed lipid lower...Continue Reading

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Citations

Aug 16, 2013·World Journal of Gastroenterology : WJG·Raffaele Pezzilli, Nico Pagano
Apr 11, 2012·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Viktória TerzinLászló Czakó
Feb 5, 2013·European Journal of Internal Medicine·Nils Ewald, Reinhard G Bretzel
Nov 27, 2018·Royal Society Open Science·Shin MukaiKazuo Tsubota
Jan 14, 2021·Avicenna Journal of Medicine·Mujeeb Z BandaySaniya Nissar
Jul 16, 2021·Current Opinion in Gastroenterology·Phil A HartMark O Goodarzi

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