Diabetes, hyperglycaemia, and acute ischaemic stroke

Lancet Neurology
Merel J A LuitseL Jaap Kappelle

Abstract

Diabetes and ischaemic stroke often arise together. People with diabetes have more than double the risk of ischaemic stroke after correction for other risk factors, relative to individuals without diabetes. Multifactorial treatment of risk factors for stroke-in particular, lifestyle factors, hypertension, and dyslipidaemia-will prevent a substantial number of these disabling strokes. Hyperglycaemia occurs in 30-40% of patients with acute ischaemic stroke, also in individuals without a known history of diabetes. Admission hyperglycaemia is associated with poor functional outcome, possibly through aggravation of ischaemic damage by disturbing recanalisation and increasing reperfusion injury. Uncertainty surrounds the question of whether glucose-lowering treatment for early stroke can improve clinical outcome. Achievement of normoglycaemia in the early stage of stroke can be difficult, and the possibility of hypoglycaemia remains a concern. Phase 3 studies of glucose-lowering therapy in acute ischaemic stroke are underway.

References

Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S SadoshimaM Fujishima
May 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M J QuastT A Kent
Jan 14, 2000·JAMA : the Journal of the American Medical Association·J B MeigsP W Wilson
Apr 14, 2000·BMJ : British Medical Journal·R DonnellyA D Morris
Feb 24, 2001·Diabetologia·E A Gale, K M Gillespie
Oct 6, 2001·Stroke; a Journal of Cerebral Circulation·S E CapesH C Gerstein
Jan 17, 2002·The New England Journal of Medicine·G van den BergheR Bouillon
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
Sep 17, 2002·The American Journal of Cardiology·Deepak L BhattEric J Topol
Nov 2, 2002·Stroke; a Journal of Cerebral Circulation·E J CunninghamUNKNOWN European Carotid Surgery Trialists' Collaborative Group
Dec 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ingrid Fleming, Rudi Busse
Feb 20, 2003·Diabetes/metabolism Research and Reviews·Anders GreenStig Krøger Pramming
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·Salah-Eddine MegherbiUNKNOWN European BIOMED Study of Stroke Care Group
May 17, 2003·Stroke; a Journal of Cerebral Circulation·Thomas HillenUNKNOWN South London Stroke Register
May 29, 2003·The Journal of Thoracic and Cardiovascular Surgery·Anthony P FurnaryAlbert Starr
Jul 12, 2003·The Diabetes Educator·Tiffany L GaryFrederick L Brancati
May 13, 2004·Postgraduate Medical Journal·P English, G Williams
Apr 13, 2005·Lancet·Michael StumvollTimon W van Haeften
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Jul 9, 2005·Stroke; a Journal of Cerebral Circulation·Marc RiboJosé Alvarez-Sabín
Aug 3, 2005·Circulation·Jacqueline M DekkerRobert J Heine
Dec 24, 2005·The New England Journal of Medicine·David M NathanUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research
Mar 15, 2006·Lancet·Denis Daneman
Aug 26, 2006·Stroke; a Journal of Cerebral Circulation·Tetsuya OhiraAaron R Folsom
Jan 24, 2007·Lancet Neurology·Kathleen StrongRuth Bonita
Apr 17, 2007·Neurochemistry International·Chantal BémeurJane Montgomery
May 4, 2007·The New England Journal of Medicine·Alan M JacobsonJudith Harth

❮ Previous
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Citations

Mar 20, 2013·BioMed Research International·D LévigneB Pittet-Cuénod
May 14, 2014·Regulatory Peptides·Vladimer DarsaliaCesare Patrone
Aug 3, 2014·Translational Stroke Research·Emmanuel I González-MorenoFernando Góngora-Rivera
Nov 1, 2012·Immunity & Ageing : I & a·Aliaksei KisialiouCarmine Vecchione
Jan 30, 2013·Diabetes Care·Davar NikneshanUNKNOWN Stroke Outcomes Research Canada (SORCan) Working Group
Sep 18, 2015·BMJ Open Diabetes Research & Care·Natalie NanayakkaraElif I Ekinci
Jan 28, 2016·Journal of Diabetes Investigation·Onno N GroeneveldGeert Jan Biessels
Mar 1, 2016·Acta neurochirurgica·Oliver von OlnhausenGastón Schechtmann
Mar 5, 2016·Annals of Medicine·Lia Alves-CabratosaRafel Ramos
Mar 3, 2015·Lancet Neurology·Paula S KoekkoekGeert Jan Biessels
Aug 10, 2015·Psychoneuroendocrinology·Juan Jose Ramos-RodriguezMonica Garcia-Alloza
Dec 17, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Heather M SnyderMaria C Carrillo
Dec 15, 2012·The Mount Sinai Journal of Medicine, New York·Jason C Kovacic, Valentin Fuster
Oct 16, 2015·Nature Reviews. Neuroscience·Geert Jan Biessels, Lawrence P Reagan
Apr 15, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Manon BrundelGeert Jan Biessels
Feb 10, 2016·Clinical and Experimental Pharmacology & Physiology·Vivek SrinivasanDaniel K Y Chan
Jul 15, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Juan ShouXiangjie Zhang
Aug 14, 2012·Experimental Gerontology·L G ExaltoG J Biessels
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Geert Jan BiesselsRachel A Whitmer
Jun 23, 2012·The International Journal of Neuroscience·Shadi YaghiNicolas Bianchi
Aug 15, 2014·Expert Opinion on Drug Discovery·Mikkel ChristensenFilip K Knop
Jul 21, 2015·Revista clínica española·L Castilla-GuerraJ Hewitt
Jul 15, 2015·Molecular Neurobiology·Juan José Ramos-RodriguezMónica Garcia-Alloza
May 21, 2013·Journal of the American College of Cardiology·Raffaele MarfellaGiuseppe Paolisso
Sep 17, 2013·Cell Metabolism·Adrian Kee Keong TeoRohit N Kulkarni
Mar 31, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·HongNa YangCuiLan Wang
Mar 21, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Bryan A LieberE Sander Connolly
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Cesare PatroneDan Lindholm
Jul 23, 2013·European Journal of Pharmacology·Geert Jan Biessels
Jun 17, 2014·Diabetes·Geert Jan Biessels, Yael D Reijmer

❮ Previous
Next ❯

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