Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation

Frontiers in Pharmacology
Nathanne S FerreiraRita C Tostes

Abstract

Aldosterone promotes non-genomic effects in endothelial and vascular smooth muscle cells via activation of mineralocorticoid receptors (MR) and G protein-coupled estrogen receptors (GPER). GPER activation is associated with beneficial/protective effects in the vasculature. Considering that vascular dysfunction plays a major role in diabetes-associated complications, we hypothesized that the beneficial effects mediated by vascular GPER activation, in response to aldosterone, are decreased in diabetes. Mesenteric resistance arteries from female, 14-16 weeks-old, control and diabetic (db/db) mice were used. Phenylephrine (PhE)-induced contractions were greater in arteries from db/db vs. control mice. Aldosterone (10 nM) increased maximal contractile responses to PhE in arteries from control mice, an effect elicited via activation of GPER. Although aldosterone did not increase PhE responses in arteries from db/db mice, blockade of GPER, and MR decreased PhE-induced contractile responses in db/db mesenteric arteries. Aldosterone also reduced the potency of acetylcholine (ACh)-induced relaxation in arteries from both control and db/db mice via MR-dependent mechanisms. GPER antagonism further decreased ACh-induced relaxation in the co...Continue Reading

References

Oct 1, 1983·American Journal of Epidemiology·E Barrett-Connor, D L Wingard
Feb 1, 1995·Circulation Research·L P AdamD R Hathaway
Apr 1, 1998·Archives of Internal Medicine·J R Sowers
Jul 6, 2000·British Journal of Pharmacology·A S De VrieseP M Vanhoutte
Feb 15, 2001·Journal of Vascular Research·K L Christensen, M J Mulvany
Feb 4, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Justine Davies, Allan Struthers
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Samy I McFarlane, James R Sowers
Jun 19, 2003·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D P ToledoZ B Fortes
Aug 27, 2003·The Journal of Biological Chemistry·Alexander W KrugMichael Gekle
Apr 17, 2004·Kidney International·Norman K HollenbergNaomi D L Fisher
Feb 9, 2005·Hypertension·Glaucia E CalleraErnesto L Schiffrin
Apr 22, 2005·British Journal of Clinical Pharmacology·J DaviesA Struthers
Jan 25, 2006·Hypertension·Ernesto L Schiffrin
Feb 9, 2006·Gender Medicine·Marianne McCollumPatrick W Sullivan
Jul 25, 2006·Gender Medicine·Marianne J LegatoUNKNOWN Writing Group for The Partnership for Gender-Specific Medicine
Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Aditya GoelRoshanak Rahimian
Oct 28, 2009·Journal of Cardiovascular Pharmacology·Jane A Leopold
Feb 18, 2011·Journal of Cardiovascular Pharmacology·Sarah H LindseyMark C Chappell
Jan 5, 2012·Hypertension·Adam Whaley-Connell, James R Sowers
Nov 23, 2012·Journal of Vascular Research·Marie Briet, Ernesto L Schiffrin
Jan 4, 2013·American Journal of Physiology. Cell Physiology·Robert GrosRoss D Feldman
May 16, 2013·American Journal of Physiology. Endocrinology and Metabolism·Sarah H LindseyMark C Chappell
Aug 2, 2013·Clinical and Experimental Pharmacology & Physiology·Ross D Feldman, Robert Gros
Feb 18, 2014·Molecular and Cellular Endocrinology·Eric R Prossnitz, Matthias Barton
Mar 14, 2014·The Lancet. Diabetes & Endocrinology
Aug 29, 2014·Endocrinology·Brasilina CarocciaGian Paolo Rossi
Sep 23, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Heba AdelMohamed M A Khalifa

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Citations

Oct 21, 2015·Trends in Endocrinology and Metabolism : TEM·Ross D Feldman, Lee E Limbird
Mar 30, 2017·The Journal of Endocrinology·Stefanie RuhsClaudia Grossmann
Mar 28, 2020·Cardiovascular Research·Quynh Nhu DinhChristopher G Sobey
Aug 22, 2020·American Journal of Hypertension·Nathanne S FerreiraErnesto L Schiffrin
Sep 8, 2020·American Journal of Physiology. Renal Physiology·Eman Y Gohar
May 8, 2016·Clinical Science·Margaret A ZimmermanSarah H Lindsey
Dec 13, 2016·Heart Failure Reviews·Milla Marques HermidorffMauro César Isoldi
Mar 11, 2016·American Journal of Physiology. Renal Physiology·Sergi ClotetMaria José Soler
Jul 5, 2019·Pharmacology & Therapeutics·M Elizabeth MossIris Z Jaffe

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