Diabetes increases inflammation and lung injury associated with protective ventilation strategy in mice

International Immunopharmacology
Xiang-qing XiongLi-na Lin

Abstract

Mechanical ventilation may paradoxically cause lung injury. Protective mechanical ventilation strategy utilizing low tidal volume and high frequency has been shown to attenuate inflammation and reduce mortality in non-diabetic patients. The purpose of this present study was to observe the effects of diabetes on inflammation and lung injury in mice with protective ventilation strategy. Forty mice were included in our study. The mice in Group Dia-MV and Con-MV were subjected to 4 hour-ventilation. And the mice in Group Dia-SB and Con-SB were exposed to room air breathing spontaneously for 4h. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), superoxide dismutase (SOD) and malondialdehyde (MDA) levels in serum were detected and the expression of inflammatory cytokine mRNA was also determined in lung tissue. Lung damage was assessed using a modified lung injury score. The serum levels of TNF-α, IL-6, and IL-10 in Group Dia-MV were significantly higher than those in Group Dia-SB or Group Con-MV or Group Con-SB (P<0.05). Quantitative RT-PCR analysis of pro-inflammatory cytokines in lung homogenates presented similar results. The mice in Group Dia-MV suffered obvious lung histological changes, whose lung i...Continue Reading

References

Jul 1, 1990·Archives of Internal Medicine·M Sandler
Feb 5, 1998·The New England Journal of Medicine·M B AmatoC R Carvalho
Feb 12, 1999·Respiration; International Review of Thoracic Diseases·B WeynandJ Rahier
Jun 19, 2001·The European Respiratory Journal·R A VeldhuizenL McCaig
Jan 30, 2004·Diabetes·Katherine GreenMichael P Murphy
Nov 25, 2004·Diabetes Care·Earl S FordUNKNOWN National Health and Nutrition Examination Survey Epidemiologic Follow-up Study
Jan 15, 2008·Journal of Diabetes and Its Complications·Canan HürdağCihan Demirci

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Citations

Dec 17, 2014·Experimental Lung Research·Lu-Mei WangYu-Jian Liu
Nov 18, 2014·International Journal of Experimental Pathology·Dietmar ZechnerBrigitte Vollmar
Jul 21, 2016·Nuclear Medicine and Biology·Vanessa Coelho GóesJosé Roberto Machado-Silva
Feb 17, 2017·Aging and Disease·Hong ZhengLiang-Jun Yan
Jul 4, 2018·Oxidative Medicine and Cellular Longevity·Andrzej FedorowiczStefan Chlopicki
Jun 30, 2021·Acta Physiologica·Liz Maria Queiroz MachadoMaria Diana Moreira-Gomes

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