Diabetes-induced abnormalities of mitochondrial function in rat brain cortex: the effect of n-3 fatty acid diet

Molecular and Cellular Biochemistry
Maria ChomovaJana Muchova

Abstract

Diabetic encephalopathy, a proven complication of diabetes is associated with gradually developing end-organ damage in the CNS increasing the risk of stroke, cognitive dysfunction or Alzheimer's disease. This study investigated the response of rat cortical mitochondria to streptozotocin-induced diabetes and the potential for fish oil emulsion (FOE) to modulate mitochondrial function. Diabetes-induced deregulation of the respiratory chain function as a result of diminished complex I activity (CI) and cytochrome c oxidase hyperactivity was associated with attenuation of antioxidant defense of isolated cortical mitochondria, monitored by SOD activity, the thiol content, the dityrosine and protein-lipid peroxidation adduct formation. A parallel reduction in phosphorylation of the energy marker AMPK has pointed out to disrupted energy homeostasis. Dietary FOE administration partially preserved CI activity, restored AMPK phosphorylation, but was unable to attenuate oxidative stress and prevent the shift toward saturated fatty acids in the cardiolipin composition. Moreover, diabetes has induced alterations in the protein expression of the regulatory COX4 subunit of cytochrome c oxidase, in the inhibitory factor IF1 and ATP5A subunit o...Continue Reading

References

Mar 1, 1992·The Biochemical Journal·M Cardamone, N K Puri
Jan 1, 1987·Methods in Enzymology·P C Jocelyn
Sep 30, 1970·Biochemical and Biophysical Research Communications·J O HolloszyP A Molé
Aug 11, 1982·Biochimica Et Biophysica Acta·J Slavík
Jan 1, 1994·Methods in Enzymology·H Shimasaki
Jan 1, 1994·Methods in Enzymology·C Giulivi, K J Davies
Nov 18, 1997·European Journal of Biochemistry·S Arnold, B Kadenbach
Apr 25, 2000·The EMBO Journal·H Schägger, K Pfeiffer
Jun 6, 2000·Biochimica Et Biophysica Acta·D W Green, G J Grover
Feb 6, 2002·Chembiochem : a European Journal of Chemical Biology·F Bordusa
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Klára KitajkaTibor Farkas
Jul 23, 2003·Molecular and Cellular Biochemistry·Peter KaplanDusan Dobrota
Aug 19, 2003·Nature Structural Biology·Elena CabezónJohn E Walker
Oct 29, 2003·Chemistry and Physics of Lipids·William Stillwell, Stephen R Wassall
Nov 5, 2003·Diabetologia·T den HeijerM M B Breteler
Apr 20, 2004·European Journal of Pharmacology·Augustina M A BrandsGeert Jan Biessels
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Klára KitajkaLászló G Puskás
Oct 11, 2005·The Journal of Endocrinology·R MastrocolaG Boccuzzi
Oct 15, 2005·Nature Reviews. Neuroscience·Zane B AndrewsTamas L Horvath
Oct 18, 2005·Neurobiology of Aging·Lawrence P Reagan
Jan 25, 2006·Lipids in Health and Disease·Ho-Joo LeeRichard P Bazinet
Mar 23, 2006·The Journal of Biological Chemistry·Carsten BornhövdAndreas S Reichert
Oct 18, 2006·Biochemistry·José J GarcíaJosé S Rodríguez-Zavala
Feb 13, 2007·Apoptosis : an International Journal on Programmed Cell Death·François Gonzalvez, Eyal Gottlieb
Oct 11, 2007·Redox Report : Communications in Free Radical Research·Peter KaplanDusan Dobrota
Nov 21, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J Thomas Brenna, Guan-Yeu Diau
Nov 27, 2007·FEBS Letters·Joseph T RodgersPere Puigserver
Mar 8, 2008·The EMBO Journal·Mike StraussWerner Kühlbrandt
Apr 15, 2008·European Journal of Pharmacology·Cynthia Jongen, Geert Jan Biessels
Jul 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Henk M De FeyterJeanine J Prompers

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