Diabetes-induced alterations of reproductive and adrenal function in the female rat

Neuroendocrinology
C T ValdesD G Rogers

Abstract

Diabetes interferes with reproductive function in laboratory animals. Previous studies in female diabetic rats have not resolved if the reproductive abnormalities observed are at the hypothalamic, pituitary and/or ovarian level. The interaction of the gonadal and adrenal axes has not been studied in the diabetic female rat. The purpose of this study is twofold: first, to determine the level of dysfunction in the hypothalamic-pituitary axis caused by diabetes in the adult female rat controlling for stage of the estrous cycle, and, second, to evaluate basal corticosterone secretion in female diabetic rats. Sixty cycling 40-day-old female rats were randomly assigned to 3 groups; control (n = 32), diabetic (n = 14), and diabetic insulin-replaced animals (n = 14). The level of hyperglycemia in each group was documented by glycosylated hemoglobin levels and biweekly blood glucoses. Three weeks after induction of diabetes, pituitary luteinizing hormone (LH) responsiveness following an i.v. injection of gonadotropin-releasing hormone (GnRH) was assessed in representative diestrous rats from each group. All animals were sacrificed in either diestrus or proestrus for determination of GnRH concentration in the hypothalamus, LH and follicl...Continue Reading

Citations

Nov 1, 1993·Neuroscience and Behavioral Physiology·T V El'tsevaV N Babichev
Jan 1, 1995·Neuroscience and Behavioral Physiology·V N BabichevT A Peryshkova
Sep 14, 2001·Journal of Sex & Marital Therapy·K ParkJ H Nam
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Apr 22, 2011·Archives of Oral Biology·Eliana Tiemi MaekawaEduardo José Caldeira
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