Diabetes induced changes in rat mesenchymal stem cells

Cells, Tissues, Organs
Alexandra StolzingAndy Scutt

Abstract

Diabetes mellitus, the single most important cause of vascular disease in the industrialized world, is also associated with bone loss and impaired fracture healing. Mesenchymal stem cells (MSCs) have the potential to differentiate into osteoblasts, chondrocytes and adipocytes and other mesenchymal cells and play a central role in bone formation and repair. Because of this, we have investigated the possibility that diabetes has direct effects on MSCs in vivo and that this might represent a cellular basis for diabetes-induced osteoporosis. We isolated MSCs from rats with streptozotocin-induced diabetes and analysed them ex vivo for their ability to proliferate and differentiate in the fibroblastic colony-forming unit assay. Effects of diabetes on bone metabolism in vivo were determined by analysing tibiae from control and diabetic animals by quantitative computerized tomography. The total number of colonies and osteoblastic colonies staining positive for alkaline phosphatase were quantified and both colony size and number were found to be significantly reduced in diabetic rats. The changes appear to be mediated by the induction of apoptosis and senescence by advanced glycation end products (AGEs), together with an increase in the...Continue Reading

Citations

Sep 17, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tamás Roszer
Oct 12, 2012·In Vitro Cellular & Developmental Biology. Animal·Yi-Qun LuXing-Bo Cheng
Apr 3, 2012·Stem Cells and Development·Alexandra StolzingAndrew Scutt
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Zheng Zhou, Wen-Cheng Xiong
Feb 14, 2015·Expert Opinion on Therapeutic Targets·Wu Qi NanChen Bing
Aug 9, 2011·Experimental Diabetes Research·Stella BernardiPaola Secchiero
May 17, 2013·Kidney International·Mojca GasparitschBärbel Lange-Sperandio
Mar 2, 2016·Journal of Cellular and Molecular Medicine·Chao SunYue Zhou
Dec 24, 2011·International Journal of Biomaterials·A StolzingA Scutt
Sep 30, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael Hadjiargyrou, Regis J O'Keefe
Feb 24, 2015·Journal of Cellular Biochemistry·J C SilvaP S Gomes
Aug 10, 2015·Current Osteoporosis Reports·Hongli JiaoDana T Graves
May 10, 2012·Ageing Research Reviews·Yan PengXiaobing Fu
May 7, 2015·International Orthopaedics·Liu ShiChen Wang
Apr 11, 2015·International Journal of Oral Science·Ying-Ying WuDana T Graves
May 25, 2015·Current Diabetes Reports·Per-Ola CarlssonKatarina Le Blanc
Apr 16, 2015·Journal of Osteoporosis·Tayyab S Khan, Lisa-Ann Fraser
May 2, 2014·Frontiers in Endocrinology·Hiroki Mizukami, Soroku Yagihashi
Jun 14, 2016·Stem Cells International·Shujing LiQuanhai Li
Mar 30, 2011·The International Journal of Lower Extremity Wounds·Robert BlakytnyEdward B Jude
Nov 22, 2017·Tissue Engineering. Part a·Shin-Young ParkYang-Jo Seol
Aug 4, 2018·Cell and Tissue Research·Jafar RezaieMalek Soleimani Mehranjani
Oct 4, 2018·Diabetes·Mohammed A AlharbiDana T Graves
Mar 23, 2019·Expert Opinion on Biological Therapy·Nina KosaricGeoffrey C Gurtner
Apr 30, 2019·Journal of Cellular Physiology·Yanan KongYu Zhao
May 24, 2017·Molecular Medicine Reports·Takao AikawaHiroyuki Tsuchiya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.