Diabetes insipidus as a complication of Wegener's granulomatosis and its treatment with biologic agents.

International Journal of Rheumatology
Joanna Rosalind CunningtonJohn Isaacs

Abstract

Wegener's granulomatosis of the pituitary gland resulting in diabetes insipidus is a rare complication of the disease. Standard treatment for Wegener's granulomatosis involves a combination of prednisolone and cylophosphamide, however biologic agents are now being used in refractory cases. We report three cases of patients with diabetes insipidus as a complication of Wegener's granulomatosis who were treated with biologic agents. All three cases showed clinical response to treatment with biologic agents including rituximab and alemtuzumab and two cases demonstrated improvement in pituitary gland abnormalities by MRI. Clinicians should be aware that diabetes insipidus can present as a complication of Wegener's granulomatosis and that biologic therapies may be effective in refractory cases.

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Citations

Jan 1, 2014·Arthritis Care & Research·Joel Hua-Liang LimBernard Yu-Hor Thong
Aug 26, 2019·Clinical Rheumatology·Arturo Vega-BeyhartDaniel Cuevas-Ramos
Mar 26, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Tuck Yean Yong, Jordan Yuanzhi Li
Mar 26, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Ahmad Al-FakhouriAntoine G Sreih
Aug 12, 2018·Neuroradiology·N C AdamsS Looby
Nov 29, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jing HughesWhitney W Woodmansee

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Methods Mentioned

BETA
ESR
biopsy

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